INT339476

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.57
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Eif2ak2) nucleus (Eif2ak2) intracellular (Eif2ak2)
translation (Eif2ak2) kinase activity (Eif2ak2)
Anatomy Link Frequency
macrophage 3
fibroblasts 1
Eif2ak2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 294 97.04 Very High Very High Very High
cytokine 35 74.88 Quite High
Inflammation 56 74.52 Quite High
palliative 7 24.88 Low Low
agonist 21 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
addiction 7 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 21 98.80 Very High Very High Very High
Disease 14 85.56 High High
INFLAMMATION 63 74.52 Quite High
Sepsis 70 40.24 Quite Low
Infection 35 5.00 Very Low Very Low Very Low
Bacterial Infection 7 5.00 Very Low Very Low Very Low
Necrosis 7 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 7 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In investigating the TLR4-mediated regulation of PKR, we discovered that PKR itself was a target of macrophage reprogramming and was negatively regulated in endotoxin-tolerized cells.
Regulation (regulated) of PKR in macrophage
1) Confidence 0.28 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.16 Pain Relevance 0.22
Total immunoprecipitable PKR protein levels were not significantly altered over time in naive cells (Fig. 3B and C).
Neg (not) Regulation (altered) of PKR
2) Confidence 0.28 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0.10
In investigating the TLR4-mediated regulation of PKR, we discovered that PKR itself was a target of macrophage reprogramming and was negatively regulated in endotoxin-tolerized cells.
Regulation (target) of PKR in macrophage
3) Confidence 0.28 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.16 Pain Relevance 0.22
In investigating the TLR4-mediated regulation of PKR, we discovered that PKR itself was a target of macrophage reprogramming and was negatively regulated in endotoxin-tolerized cells.
Spec (investigating) Regulation (regulation) of PKR in macrophage
4) Confidence 0.21 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.16 Pain Relevance 0.23
PKR activity has not heretofore been shown to be regulated by Ub.
Regulation (regulated) of PKR
5) Confidence 0.13 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0.10
To assay for the potential in vivo significance of SOCS-1 in regulating PKR activity, we obtained SOCS-1 knockout mouse embryonic fibroblasts (MEFs) and ascertained LPS-responsive PKR activation in naive and LPS-tolerized cells.
Regulation (regulating) of PKR in fibroblasts associated with targeted disruption
6) Confidence 0.13 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.10 Pain Relevance 0
Since the effects of SOCS-1 on PKR protein levels may be the result of regulation of an intermediate element, we evaluated the potential for SOCS-1 and PKR to interact physically in our overexpression system.
Regulation (regulation) of PKR
7) Confidence 0.13 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0

General Comments

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