INT339480

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak3) nucleus (Irak3) kinase activity (Irak3)
cytoplasm (Irak3)
Anatomy Link Frequency
macrophages 2
Irak3 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 42 90.60 High High
Inflammation 8 65.52 Quite High
cytokine 5 64.48 Quite High
agonist 3 39.44 Quite Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 65.52 Quite High
Infection 5 46.88 Quite Low
Sepsis 10 43.32 Quite Low
Disease 2 43.04 Quite Low
Necrosis 1 14.80 Low Low
Cancer 1 14.44 Low Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Bacterial Infection 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contrary to the upregulation of IRAK-M, the critical signaling kinase, IRAK-1, is downregulated at the levels of protein and RNA in endotoxin-tolerant macrophages (17, 18).
Negative_regulation (downregulated) of Positive_regulation (upregulation) of IRAK-M in macrophages
1) Confidence 0.05 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.12 Pain Relevance 0.41

General Comments

This test has worked.

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