INT339495

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.58
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tlr4, Eif2ak2) signal transduction (Tlr4) RNA binding (Eif2ak2)
nucleus (Eif2ak2) plasma membrane (Tlr4) translation (Eif2ak2)
Anatomy Link Frequency
macrophages 1
fibroblasts 1
Tlr4 (Mus musculus)
Eif2ak2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 210 99.20 Very High Very High Very High
cytokine 25 82.48 Quite High
Inflammation 40 82.12 Quite High
addiction 5 78.88 Quite High
agonist 15 71.24 Quite High
palliative 5 68.12 Quite High
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 98.96 Very High Very High Very High
Stress 5 94.84 High High
Disease 10 93.16 High High
INFLAMMATION 45 82.12 Quite High
Sepsis 50 80.96 Quite High
Infection 25 8.12 Low Low
Bacterial Infection 5 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that PKR activation is not a feature of all TLRs, as evidenced by the fact that PKR is activated by TLR4 and TLR3 but not by TLR2.
TLR4 Neg (not) Positive_regulation (activated) of PKR
1) Confidence 0.21 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.09 Pain Relevance 0.16
As it is possible that tolerant macrophages may simply exhibit delayed kinetics of PKR activation, additional time courses of activation to 180 min were carried out, with no LPS-mediated increase in PKR activity (data not shown).
LPS Positive_regulation (increase) of PKR in macrophages
2) Confidence 0.12 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0.04
To assay for the potential in vivo significance of SOCS-1 in regulating PKR activity, we obtained SOCS-1 knockout mouse embryonic fibroblasts (MEFs) and ascertained LPS-responsive PKR activation in naive and LPS-tolerized cells.
LPS Positive_regulation (activation) of PKR in fibroblasts associated with targeted disruption
3) Confidence 0.12 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.10 Pain Relevance 0.03
In an attempt to expand our understanding of signaling in tolerance/reprogramming, we have discovered that PKR, shown previously to be activated by LPS, is an additional signaling element that is subject to tolerance.
LPS Positive_regulation (activated) of PKR associated with tolerance
4) Confidence 0.12 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.21 Pain Relevance 0.27
However, PKR has also been shown to be activated by LPS through TLR4 (24–26), although the precise role of PKR in mediating the response to endotoxin is not clear.
LPS Positive_regulation (activated) of PKR
5) Confidence 0.12 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.18 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox