INT3395

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 4.23
Pain Relevance 5.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VIP)
Anatomy Link Frequency
tears 1
plasma 1
LES 1
neurons 1
nerve 1
VIP (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 117 100.00 Very High Very High Very High
qutenza 15 100.00 Very High Very High Very High
Cholecystokinin 4 100.00 Very High Very High Very High
Neurotransmitter 1 100.00 Very High Very High Very High
substance P 40 99.76 Very High Very High Very High
opiate 3 99.68 Very High Very High Very High
Calcium channel 19 99.40 Very High Very High Very High
antagonist 8 99.40 Very High Very High Very High
narcan 2 98.96 Very High Very High Very High
tetrodotoxin 4 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 56 99.98 Very High Very High Very High
Hypersensitivity 38 99.48 Very High Very High Very High
Diarrhoea 11 99.12 Very High Very High Very High
Achalasia 79 98.48 Very High Very High Very High
Somatostatinoma 4 94.08 High High
Cancer 90 93.52 High High
Disorders Of The Lacrimal System 3 88.88 High High
Congenital Anomalies 8 85.60 High High
Death 2 82.12 Quite High
Diabetes Mellitus 3 81.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effect of both capsaicin and VIP in the circular muscle was tetrodotoxin-resistant suggesting direct inhibition of muscle cells.
Negative_regulation (effect) of VIP in muscle associated with tetrodotoxin and qutenza
1) Confidence 0.59 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2253692 Disease Relevance 0 Pain Relevance 1.30
Clonidine has a poor intrinsic activity but antagonizes the action of epinephrine. (3) The inhibition of VIP action by epinephrine is reversed by the alpha antagonists dihydroergotamine, phentolamine and the alpha 2 antagonist yohimbine, while unaffected by the beta antagonist propranolol and the alpha 1 antagonist prazosin, (4) Epinephrine inhibits VIP-stimulated adenylate cyclase activity in preparations of colonic plasma membranes.
Negative_regulation (inhibition) of VIP in plasma associated with antagonist and clonidine
2) Confidence 0.57 Published 1984 Journal Peptides Section Abstract Doc Link 6147817 Disease Relevance 0 Pain Relevance 0.45
A decrease in neuronal nitric oxide synthase, vasoactive intestinal peptide, PACAP, and tyrosine hydroxylase immunopositive nerve fibers was observed in circular muscle layer while substance P immunoreactivity was increased.
Negative_regulation (decrease) of vasoactive intestinal peptide in nerve
3) Confidence 0.57 Published 2001 Journal Gastroenterology Section Body Doc Link 11487552 Disease Relevance 0.08 Pain Relevance 0
Unlabeled VIP was able to compete in a dose-dependent manner with an IC50 value of 5.2 +/- 1.3 x 10(-10) M.
Negative_regulation (compete) of VIP
4) Confidence 0.43 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2829291 Disease Relevance 0 Pain Relevance 0
Similarly, CGRP and VIP levels during a migraine headache were significantly reduced within 2 hours after sumatriptan treatment and reported symptom relief.
Negative_regulation (reduced) of VIP
5) Confidence 0.43 Published 2006 Journal Headache Section Body Doc Link 16412148 Disease Relevance 0 Pain Relevance 0
The inhibitory effect of NO, SNP, or two other putative inhibitory neurotransmitters (VIP and CGRP) on the LES was not antagonized by L-NNA.
Negative_regulation (effect) of VIP in LES associated with neurotransmitter
6) Confidence 0.42 Published 1992 Journal Life Sci. Section Abstract Doc Link 1373790 Disease Relevance 0 Pain Relevance 0.20
The immunoreactivity of vasoactive intestinal polypeptide (VIP) was found to be reduced in the oligoganglionic and aganglionic segments.
Negative_regulation (reduced) of VIP
7) Confidence 0.41 Published 1985 Journal J. Pediatr. Surg. Section Abstract Doc Link 2409261 Disease Relevance 0.16 Pain Relevance 0.21
In this study we also show that SP, CGRP, and VIP are normally present in tears of allergic subjects and increase after conjunctival allergen challenge.
Negative_regulation (present) of VIP in tears associated with hypersensitivity and substance p
8) Confidence 0.38 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.72 Pain Relevance 0.39
Patients with Raynaud's disease displayed lower levels of VIP than the normal group (median 3.7 pmol X l-1 for 20 patients; P less than 0.01 for the difference from normals).
Negative_regulation (displayed) of VIP associated with disease
9) Confidence 0.38 Published 1984 Journal Gen. Pharmacol. Section Abstract Doc Link 6714637 Disease Relevance 0.32 Pain Relevance 0.83
In rats, a postmortem delay of up to 8 hours did not affect SP, Met-Enk, PHI, or NPY and decreased SST, CCK, and VIP levels.
Neg (not) Negative_regulation (decreased) of VIP associated with somatostatin, cholecystokinin and substance p
10) Confidence 0.28 Published 1990 Journal Neurology Section Abstract Doc Link 2296359 Disease Relevance 0.17 Pain Relevance 0.76
In contrast to the brain opiates, however, the inhibitory effects of VIP, somatostatin and its analogues, and HPP were not reversed by the opiate antagonist naloxone.
Neg (not) Negative_regulation (reversed) of VIP in brain associated with antagonist, narcan, somatostatin and opiate
11) Confidence 0.17 Published 1978 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 733857 Disease Relevance 0 Pain Relevance 0.74
Recently, have been described nine cases of VIP-oma in which octreotide was very successful as adjuvant therapy for symptoms control and for reducing the serum elevated VIP levels improving the diarrhoea and the electrolyte imbalance [49-51].


Negative_regulation (reducing) of VIP associated with diarrhoea
12) Confidence 0.15 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.20 Pain Relevance 0.28
Studies [25-27] have suggested that loss of VIP and NO secreting neurons leads to an imbalance between the excitatory and inhibitory neurons of the myenteric plexus, producing irreversible manometric changes in such patients.
Negative_regulation (loss) of VIP in neurons
13) Confidence 0.09 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 1.23 Pain Relevance 0.15
Thus, CaM inhibitors such as chemical substances and peptides, may activate SOCs by interfering with the CaM-iPLA2 complex [36], [43].
Negative_regulation (inhibitors) of peptides associated with calcium channel
14) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0.30
This protein corresponds to removal of N'-terminal peptides from pro-SP-B, liberating 13–15 kDa fragments.
Negative_regulation (removal) of peptides
15) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.35 Pain Relevance 0

General Comments

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