INT339509

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tlr4, Eif2ak2) signal transduction (Tlr4) RNA binding (Eif2ak2)
nucleus (Eif2ak2) plasma membrane (Tlr4) translation (Eif2ak2)
Anatomy Link Frequency
macrophage 1
Tlr4 (Mus musculus)
Eif2ak2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 42 85.68 High High
cytokine 5 75.44 Quite High
Inflammation 8 75.08 Quite High
agonist 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 2 86.12 High High
INFLAMMATION 9 75.08 Quite High
Sepsis 10 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Bacterial Infection 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In investigating the TLR4-mediated regulation of PKR, we discovered that PKR itself was a target of macrophage reprogramming and was negatively regulated in endotoxin-tolerized cells.
TLR4 Spec (investigating) Regulation (regulation) of PKR in macrophage
1) Confidence 0.08 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.16 Pain Relevance 0.23

General Comments

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