INT339558

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 3.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2J2) endoplasmic reticulum (CYP2J2)
Anatomy Link Frequency
hearts 2
lung 1
CYP2J2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 16 14.00 Low Low
Inflammation 78 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Calcium channel 12 5.00 Very Low Very Low Very Low
ischemia 8 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 14 99.40 Very High Very High Very High
Malignant Neoplastic Disease 6 99.20 Very High Very High Very High
Skin Cancer 2 98.96 Very High Very High Very High
Cardiovascular Disease 24 97.16 Very High Very High Very High
Adenocarcinoma 2 96.52 Very High Very High Very High
Cancer 232 88.16 High High
Hypoxia 20 85.48 High High
Benign Prostatic Hypertrophy 4 72.92 Quite High
Myocardial Infarction 54 72.36 Quite High
Renal Cancer 2 47.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that CYP2J2 mRNA levels were higher in female than in male left ventricular samples.
Transcription (levels) of CYP2J2
1) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.25 Pain Relevance 0
One could suggest that the sex-dependant CYP2J2 mRNA expression explains higher susceptibility of men for the onset or progression of cardiovascular diseases.
Transcription (expression) of CYP2J2 associated with cardiovascular disease
2) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.25 Pain Relevance 0
3), they further demonstrated that gene expression for CYP2J2 and CYP1A1 was the most abundant.[26] They confirmed these results in 11 diseased and 2 normal human hearts, showing that CYP450 gene expression in the left ventricle was limited to CYP1A1, CYP2A6, CYP2B6, CYP2C8, CYP2E1, CYP2J2 and CYP4A11.[21] Recent studies conducted with quantitative real-time PCR and samples from 8 explanted human hearts indicated that CYP2J2 mRNA values were >900 times higher than those measured for CYP2C9 or CYP2C8.[12] Our results, obtained in a large cohort of human hearts, support data from these pilot studies and confirm high CYP2J2 mRNA levels in human hearts.
Transcription (values) of CYP2J2 in hearts
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.18 Pain Relevance 0
CYP2J2 mRNA levels largely exceeded (?
Transcription (levels) of CYP2J2
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.06 Pain Relevance 0
3), they further demonstrated that gene expression for CYP2J2 and CYP1A1 was the most abundant.[26] They confirmed these results in 11 diseased and 2 normal human hearts, showing that CYP450 gene expression in the left ventricle was limited to CYP1A1, CYP2A6, CYP2B6, CYP2C8, CYP2E1, CYP2J2 and CYP4A11.[21] Recent studies conducted with quantitative real-time PCR and samples from 8 explanted human hearts indicated that CYP2J2 mRNA values were >900 times higher than those measured for CYP2C9 or CYP2C8.[12] Our results, obtained in a large cohort of human hearts, support data from these pilot studies and confirm high CYP2J2 mRNA levels in human hearts.
Transcription (levels) of CYP2J2 in hearts
5) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.19 Pain Relevance 0
This study determined cardiac mRNA levels of various CYP450 isozymes involved in drug metabolism and demonstrated the prevalent expression of CYP2J2 mRNA.
Transcription (expression) of CYP2J2
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001885 Disease Relevance 0.05 Pain Relevance 0
Furthermore, CYP2J2 expression was detected in less than 50% of lung squamous cell carcinoma samples and in less than 15% of lung adenocarcinoma samples [127].
Transcription (detected) of CYP2J2 in lung associated with adenocarcinoma and skin cancer
7) Confidence 0.35 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.28 Pain Relevance 0
In contrast CYP2J2 staining was not detected in pancreatic or prostate adenocarcinoma.
Neg (not) Transcription (detected) of CYP2J2 associated with prostate cancer
8) Confidence 0.31 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.22 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox