INT339566

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.22
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2J2) endoplasmic reticulum (CYP2J2)
Anatomy Link Frequency
hind limb 2
hearts 2
CYP2J2 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 3 98.96 Very High Very High Very High
Inflammation 68 67.20 Quite High
antagonist 16 41.64 Quite Low
agonist 12 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 3 98.96 Very High Very High Very High
Reperfusion Injury 1 98.60 Very High Very High Very High
Cancer 232 98.48 Very High Very High Very High
Apoptosis 5 97.80 Very High Very High Very High
Metastasis 6 96.44 Very High Very High Very High
Myocardial Infarction 9 95.20 Very High Very High Very High
Carcinoma 6 91.68 High High
Increased Venous Pressure Under Development 2 90.84 High High
Adhesions 2 75.12 Quite High
INFLAMMATION 68 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of CYP2J2 in mice hearts decreases ischemia-reperfusion damage through production of EETs which affect the KATP channel activity and MAP kinase signalling.[25]
Positive_regulation (Increased) of Gene_expression (expression) of CYP2J2 in hearts associated with reperfusion injury and ischemia
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.69 Pain Relevance 0.08
The overexpression of CYP epoxygenases, including CYP2J2, also increased muscle capillary density in a rat ischemic hind limb model [103].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYP2J2 in hind limb
2) Confidence 0.46 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.10 Pain Relevance 0
Subsequent studies, in which CYP epoxygenase levels were manipulated, by either overexpression of CYP2J2 or antisense in the xenotransplanted tumor cell, suggest EETs may play a role in cancer metastasis [121].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYP2J2 associated with cancer and metastasis
3) Confidence 0.46 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.43 Pain Relevance 0

General Comments

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