INT33957

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Context Info
Confidence 0.68
First Reported 1986
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 2.89
Pain Relevance 9.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRL1) signal transducer activity (OPRL1)
Anatomy Link Frequency
SH-SY5Y 1
spinal cord 1
superior 1
C cells 1
SK-N-SH 1
OPRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 44 100.00 Very High Very High Very High
opioid receptor 36 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Neuropeptide 4 100.00 Very High Very High Very High
Buprenorphine 176 99.98 Very High Very High Very High
antagonist 9 99.88 Very High Very High Very High
Opioid 47 99.84 Very High Very High Very High
Spinal cord 7 99.68 Very High Very High Very High
agonist 29 99.64 Very High Very High Very High
mu opioid receptor 14 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 12 99.52 Very High Very High Very High
Cognitive Disorder 8 98.20 Very High Very High Very High
Injury 2 97.48 Very High Very High Very High
Pressure Volume 2 Under Development 3 96.64 Very High Very High Very High
Hyperalgesia 4 95.48 Very High Very High Very High
Stress 2 93.88 High High
Recurrence 2 93.32 High High
Shock 4 86.96 High High
Head Trauma 3 84.28 Quite High
Nociception 4 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin activation of ORL1 (opioid receptor-like 1 receptor) has been shown to antagonize mu receptor-mediated analgesia at the supraspinal level.
Positive_regulation (activation) of ORL1 associated with orphanin, opioid receptor and analgesia
1) Confidence 0.68 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748148 Disease Relevance 0.08 Pain Relevance 0.47
Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells: functional homology with opioid receptors.
Positive_regulation (activation) of ORL1 in ovary associated with orphanin and opioid receptor
2) Confidence 0.68 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.43
Prolonged ORL1 activation increased GRK2 levels and desensitized both receptors in SH-SY5Y cells.
Positive_regulation (activation) of ORL1 in SH-SY5Y
3) Confidence 0.65 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.09 Pain Relevance 0.30
Buprenorphine activates ORL1 in the spinal cord, which appears to be analgesic.
Positive_regulation (activates) of ORL1 in spinal cord associated with analgesic, spinal cord and buprenorphine
4) Confidence 0.54 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682375 Disease Relevance 0.07 Pain Relevance 2.38
beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells.
Positive_regulation (inactivates) of ORL1 associated with neuroblastoma
5) Confidence 0.50 Published 2000 Journal Eur. J. Pharmacol. Section Title Doc Link 10940375 Disease Relevance 0.10 Pain Relevance 0.74
This suggests that DAMGO activation of mu-opioid receptors results in GRK2 and GRK3 inactivation of ORL1 upon challenge with OFQ/N.
Positive_regulation (inactivation) of ORL1 associated with mu opioid receptor
6) Confidence 0.49 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.76
Stimulation of the OPRL1 receptors with synthetic agonists may increase threshold for activation of ethanol-related behaviour by environmental cues, and thus may reduce cue- or stress-primed relapse to ethanol consumption.
Positive_regulation (Stimulation) of OPRL1 associated with stress, agonist and recurrence
7) Confidence 0.46 Published 2009 Journal Brain Res. Section Abstract Doc Link 19501074 Disease Relevance 0.29 Pain Relevance 0.51
A 60-min activation of mu-or opioid receptor-like 1 (ORL1) opioid receptors natively expressed in BE(2)-C human neuroblastoma cells desensitized both mu- and ORL1 receptor-mediated inhibition of cAMP accumulation.
Positive_regulation (activation) of ORL1 associated with neuroblastoma and opioid receptor
8) Confidence 0.46 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.19 Pain Relevance 0.82
N-terminal modifications leading to peptide ORL1 partial agonists and antagonists.
Spec (partial) Positive_regulation (leading) of ORL1 associated with pain, antagonist and agonist
9) Confidence 0.44 Published 2003 Journal J. Pept. Res. Section Title Doc Link 14531842 Disease Relevance 0 Pain Relevance 0.75
Protein kinase C (PKC), but not ERK1/2, inhibition blocked OFQ/N-mediated GRK3 induction and mu and ORL1 receptor desensitization in BE(2)-C cells.
Positive_regulation (induction) of ORL1 receptor in C cells associated with kinase c
10) Confidence 0.44 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.07 Pain Relevance 0.52
U73122 treatment also blocked functional responses of m4 muscarinic receptor and alpha2-adrenoceptor in NG108-15 cells and three opioid receptors (mu, delta and opioid receptor-like receptor (ORL1)) in human neuroblastoma SK-N-SH cells. 1-[6-((17Beta-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-2, 5-pyrrolidinedione (U73343), an inactive analog of U73122, did not show any effect, which suggests that the blockade by U73122 of Gi-coupled receptor-mediated signaling is probably mediated through inhibition of phospholipase C, although a possible direct modification of G proteins can not be excluded.
Positive_regulation (responses) of ORL1 in SK-N-SH associated with neuroblastoma and opioid receptor
11) Confidence 0.41 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.26 Pain Relevance 0.19
Opiate receptor antagonists with increased selectivity for the kappa-receptor may be superior to naloxone in the treatment of these conditions.
Positive_regulation (increased) of kappa-receptor in superior associated with antagonist, narcan and opiate
12) Confidence 0.19 Published 1986 Journal Ann Emerg Med Section Abstract Doc Link 3022620 Disease Relevance 1.19 Pain Relevance 1.07
Nociceptin or orphanin FQ is a novel neuropeptide that activates an opioid-like G protein-coupled receptor ORL1.
Positive_regulation (activates) of orphanin FQ associated with orphanin, neuropeptide and opioid
13) Confidence 0.14 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8798582 Disease Relevance 0.16 Pain Relevance 0.46
These studies also found evidence for secretin, prostacyclin, opioid and alpha2-adrenergic receptors In support of this we found significantly high levels of mRNA for Ptgir1, Ptger1, Ptger3, Ptger4, Oprd1, Oprl1 and Adra2b.
Positive_regulation (levels) of Oprl1 associated with opioid
14) Confidence 0.12 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.08 Pain Relevance 0.14
This is believed to be due to the influence of elevated levels of endogenous CRH mediated via the endogenous opiate peptide receptor.
Positive_regulation (mediated) of opiate peptide receptor associated with opiate
15) Confidence 0.06 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9024279 Disease Relevance 0.09 Pain Relevance 0.18

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