INT339586

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (RPE) cytosol (RPE) small molecule metabolic process (RPE)
aging (TIMP3) extracellular region (TIMP3) carbohydrate metabolic process (RPE)
TIMP3 (Homo sapiens)
RPE (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 1 50.00 Quite Low
adenocard 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
interneuron 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 56 98.52 Very High Very High Very High
Apoptosis 1 96.12 Very High Very High Very High
Age-related Macular Degeneration 64 72.72 Quite High
Targeted Disruption 4 65.60 Quite High
Congenital Anomalies 2 55.20 Quite High
Night Blindness 2 54.92 Quite High
Ocular Toxicity (including Many Sub-types) 14 50.00 Quite Low
Frailty 4 38.88 Quite Low
Blindness 2 24.88 Low Low
Cataract 1 5.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In SFD, mutant TIMP3 accumulates in the RPE and Bruch's membrane, prompting the disease process [65,73,74]; TIMP3 overexpression can induce apoptosis in several cell types including RPE [75].
TIMP3 Positive_regulation (accumulates) of RPE associated with apoptosis and disease
1) Confidence 0.16 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.72 Pain Relevance 0

General Comments

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