INT339670

Context Info Confidence 0.24 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.47 Pain Relevance 0

embryo development (Acvr1) kinase activity (Acvr1)

Anatomy Link Frequency embryos 1 Acvr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 4 5.00 Spinal cord 2 5.00 cINOD 2 5.00 Central nervous system 1 5.00 alcohol 1 5.00 spinal inflammation 1 5.00 metalloproteinase 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Fibrodysplasia Ossificans Progressiva 17 99.56 Heterotopic Ossification 87 97.68 Calcification 3 47.96 Targeted Disruption 12 15.92 Injury 15 5.00 INFLAMMATION 4 5.00 Congenital Anomalies 4 5.00 Frailty 4 5.00 Brain Injury 3 5.00 Respiratory Failure 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, introducing a constitutively active ACVR1 mutation into zebrafish embryos failed to induce obvious HO even though strong ventralization due to enhanced BMP signaling was observed [20].

Positive_regulation (introducing) of ACVR1 in embryos associated with heterotopic ossification

1) Confidence 0.24 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.47 Pain Relevance 0

General Comments

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