INT339671

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Context Info
Confidence 0.36
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Acvr1) kinase activity (Acvr1)
Anatomy Link Frequency
embryos 2
Acvr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Embryonic Lethality 2 98.00 Very High Very High Very High
Heterotopic Ossification 174 95.76 Very High Very High Very High
Targeted Disruption 24 89.12 High High
Congenital Anomalies 8 78.84 Quite High
Fibrodysplasia Ossificans Progressiva 34 76.40 Quite High
Injury 30 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Frailty 8 5.00 Very Low Very Low Very Low
Calcification 6 5.00 Very Low Very Low Very Low
Brain Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We speculate that conditionally activating the caAlk2 expression with late tissue-specific Cre in future studies might generate a mouse model that is useful for study of HO.

2.2.

Positive_regulation (activating) of Gene_expression (expression) of caAlk2 associated with heterotopic ossification
1) Confidence 0.36 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.88 Pain Relevance 0
Their data indicate that low levels of caAlk2 expression are sufficient to transduce a sufficient amount of BMP signaling to compromise normal development of embryos.
Positive_regulation (sufficient) of Gene_expression (expression) of caAlk2 in embryos
2) Confidence 0.24 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.80 Pain Relevance 0

General Comments

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