INT339671

Context Info Confidence 0.36 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.67 Pain Relevance 0

embryo development (Acvr1) kinase activity (Acvr1)

Anatomy Link Frequency embryos 2 Acvr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 8 5.00 Spinal cord 4 5.00 cINOD 4 5.00 Central nervous system 2 5.00 alcohol 2 5.00 spinal inflammation 2 5.00 metalloproteinase 2 5.00 rheumatoid arthritis 2 5.00

Disease Link Frequency Relevance Heat Embryonic Lethality 2 98.00 Heterotopic Ossification 174 95.76 Targeted Disruption 24 89.12 Congenital Anomalies 8 78.84 Fibrodysplasia Ossificans Progressiva 34 76.40 Injury 30 5.00 INFLAMMATION 8 5.00 Frailty 8 5.00 Calcification 6 5.00 Brain Injury 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We speculate that conditionally activating the caAlk2 expression with late tissue-specific Cre in future studies might generate a mouse model that is useful for study of HO. 2.2.

Positive_regulation (activating) of Gene_expression (expression) of caAlk2 associated with heterotopic ossification

1) Confidence 0.36 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.88 Pain Relevance 0

Their data indicate that low levels of caAlk2 expression are sufficient to transduce a sufficient amount of BMP signaling to compromise normal development of embryos.

Positive_regulation (sufficient) of Gene_expression (expression) of caAlk2 in embryos

2) Confidence 0.24 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.80 Pain Relevance 0

General Comments

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