INT339695

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CYP3A4, TRO) small molecule metabolic process (CYP3A4) endoplasmic reticulum (CYP3A4)
enzyme binding (CYP3A4) lipid metabolic process (CYP3A4) oxidoreductase activity (CYP3A4)
CYP3A4 (Homo sapiens)
TRO (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 2 97.92 Very High Very High Very High
agonist 33 50.00 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 99.92 Very High Very High Very High
Apoptosis 8 95.68 Very High Very High Very High
Hepatotoxicity 9 91.04 High High
Hepatocellular Cancer 8 84.96 Quite High
Obesity 43 34.92 Quite Low
Toxicity 10 27.60 Quite Low
Diabetes Mellitus 22 5.00 Very Low Very Low Very Low
Insulin Resistance 6 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Fatty Liver 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRO has been shown to be metabolized by CYP3A4 (the homolog of Cyp3a1 in rodent) to a very active quinone metabolite which is able to produce reactive oxygen species via the redox/cycling or to bind to cellular proteins [40].
CYP3A4 Binding (metabolized) of TRO
1) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.57 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox