INT339707

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (TRO, CYP3A4) small molecule metabolic process (CYP3A4) endoplasmic reticulum (CYP3A4)
enzyme binding (CYP3A4) lipid metabolic process (CYP3A4) oxidoreductase activity (CYP3A4)
Anatomy Link Frequency
hepatocyte 2
TRO (Homo sapiens)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 4 84.16 Quite High
agonist 66 50.00 Quite Low
COX2 2 35.52 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 18 99.92 Very High Very High Very High
Stress 8 86.16 High High
Apoptosis 16 81.92 Quite High
Hepatocellular Cancer 16 79.52 Quite High
Lung Cancer 2 70.48 Quite High
Breast Cancer 2 62.56 Quite High
Toxicity 20 53.76 Quite High
Bladder Cancer 4 53.44 Quite High
Obesity 86 21.16 Low Low
Diabetes Mellitus 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CYP3A4 is also induced by TRO in primary human hepatocytes [71, 72] and a correlation has been observed between CYP3A4 levels and hepatocyte sensitivity to glitazone [73].
TRO Positive_regulation (induced) of CYP3A4 in hepatocyte
1) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.67 Pain Relevance 0.04
CYP3A4 and CYP2B6 were induced by TRO [34] and only CYP2B6 by ROSI and PIO [35] in primary human hepatocytes.
TRO Positive_regulation (induced) of CYP3A4 in hepatocytes
2) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.30 Pain Relevance 0

General Comments

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