INT339711

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TRO, PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
DNA binding (PPARA) lipid metabolic process (PPARA) cytoplasm (TRO)
Anatomy Link Frequency
brown fat 1
TRO (Homo sapiens)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 33 65.08 Quite High
Inflammatory response 2 6.24 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 2 100.00 Very High Very High Very High
Obesity 43 95.76 Very High Very High Very High
Disorder Of Lipid Metabolism 2 86.40 High High
Diabetes Mellitus 22 77.08 Quite High
INFLAMMATION 4 6.24 Low Low
Toxicity 10 5.00 Very Low Very Low Very Low
Hepatotoxicity 9 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 8 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Insulin Resistance 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed in aP2/DTA mice, whose white and brown fat is virtually eliminated by fat-specific expression of diphterin toxin A chain, TRO alleviated hyperglycemia without affecting PPAR?
TRO Neg (without) Regulation (affecting) of PPAR in brown fat associated with hyperglycemia
1) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.97 Pain Relevance 0.06

General Comments

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