INT339740

Context Info Confidence 0.18 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.41 Pain Relevance 0

mitochondrion (PCK2) small molecule metabolic process (PCK2) lyase activity (PCK2) carbohydrate metabolic process (PCK2)

PCK2 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 66 50.00 cytokine 4 5.00 Inflammatory response 4 5.00 Bile 4 5.00 COX2 2 5.00 Inflammation 2 5.00 Paracetamol 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Obesity 86 85.60 Hepatocellular Cancer 16 69.76 Osteogenic Sarcomas 2 30.28 Death 6 24.80 Stress 8 23.68 Diabetes Mellitus 44 5.00 Toxicity 20 5.00 Hepatotoxicity 18 5.00 Apoptosis 16 5.00 Insulin Resistance 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, ROSI and PIO were more potent than TRO in activating Pepck and Pdk4 and repressing regulator of G-protein signaling 2 (Rgs2).

Positive_regulation (activating) of Pepck

1) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.22 Pain Relevance 0

For example, pepck, pyruvate dehydrogenase kinase 4 (Pdk4) and c-Cbl-associated protein (Cap) were activated by the three compounds but with different time-curves, suggesting different mechanisms of gene regulation.

Positive_regulation (activated) of pepck

2) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.20 Pain Relevance 0

General Comments

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