INT339751

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 4.57
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (TRO) plasma membrane (TRO) nucleus (TRO)
cytoplasm (TRO)
Anatomy Link Frequency
liver 1
fat 1
TRO (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 7 94.48 High High
Bile 14 90.08 High High
Inflammation 7 82.16 Quite High
cytokine 14 74.64 Quite High
agonist 231 66.64 Quite High
Inflammatory response 14 5.00 Very Low Very Low Very Low
COX2 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 14 99.52 Very High Very High Very High
Injury 14 99.40 Very High Very High Very High
Toxicity 70 98.52 Very High Very High Very High
Obesity 301 95.00 High High
Diabetes Mellitus 154 91.92 High High
Hepatotoxicity 63 91.76 High High
Disorder Of Lipid Metabolism 14 87.96 High High
Apoptosis 56 87.84 High High
Parkinson's Disease 7 87.16 High High
Gallstones 7 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
target genes such as Cd36 were also induced by TRO treatment in lean mice without induction of PPAR?
Gene_expression (treatment) of TRO
1) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 1.05 Pain Relevance 0
The daily dose necessary for TRO therapeutic efficacy was 200 to 600?
Gene_expression (efficacy) of TRO
2) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.29 Pain Relevance 0
Most in vitro studies have been performed with TRO concentrations of 50??
Gene_expression (concentrations) of TRO
3) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.38 Pain Relevance 0
M, TRO modulated 5754 and 7266 genes, respectively, in at least one donor but only 4 and 29 genes in the 5 donors, respectively (Figure 2).
Gene_expression (modulated) of TRO
4) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.05 Pain Relevance 0
However, chemical inhibition of drug metabolizing enzymes involved in TRO metabolism did not protect against TRO-induced toxicity.
Gene_expression (metabolism) of TRO associated with toxicity
5) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.68 Pain Relevance 0.14
(whose mitochondrial antioxidant defense is slightly compromised), low repeated doses of TRO resulted in an oxidant injury to liver mitochondria, giving further support to mitochondria as targets for TRO-induced liver injury [41].
Gene_expression (resulted) of TRO in liver associated with injury
6) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 1.19 Pain Relevance 0.25
Indeed in aP2/DTA mice, whose white and brown fat is virtually eliminated by fat-specific expression of diphterin toxin A chain, TRO alleviated hyperglycemia without affecting PPAR?
Gene_expression (expression) of TRO in fat associated with hyperglycemia
7) Confidence 0.10 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.91 Pain Relevance 0.06

General Comments

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