INT339762

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 0.04

endosome (LAMTOR1) Golgi apparatus (LAMTOR1) plasma membrane (LAMTOR1) lysosome (LAMTOR1)

Anatomy Link Frequency adipocyte 1 LAMTOR1 (Homo sapiens)

Pain Link Frequency Relevance Heat COX2 1 72.56 agonist 33 50.00 Bile 2 48.44 cytokine 2 5.00 Inflammatory response 2 5.00 Inflammation 1 5.00 Paracetamol 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 8 93.72 Toxicity 10 88.88 Hepatocellular Cancer 8 84.08 Hepatotoxicity 9 64.20 Bladder Cancer 2 61.04 Stress 4 50.44 Breast Cancer 1 18.48 Obesity 43 5.00 Diabetes Mellitus 22 5.00 Insulin Resistance 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cell arrest was associated with increased expression of a cascade of cyclin-dependent kinase inhibitors, that is, cdki p21, p27, and p18 that each plays a crucial role in adipocyte differentiation through PPAR?

Gene_expression (cdki) of p18 in adipocyte

1) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.67 Pain Relevance 0.04

General Comments

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