INT339785

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
osteoclast 2
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 1 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 8 95.08 Very High Very High Very High
Hypercalcemia 10 93.48 High High
Osteoporosis 36 49.28 Quite Low
Hip Fractures 1 15.52 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Femoral Fractures 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Postmenopausal Osteoporosis 1 5.00 Very Low Very Low Very Low
Abdominal Cramps 1 5.00 Very Low Very Low Very Low
Vomiting 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B ligand (RANK-L) likely plays a key role, and the expression of RANK-L is significantly increased in osteoblasts and stromal cells when stimulated by glucocorticoids.11 Macrophage colony-stimulating factor levels are also increased with exposure to glucocorticoids through increased nuclear transcription of the macrophage colony-stimulating factor gene.11 RANK-L and macrophage colony-stimulating factor both play pivotal roles in inducing osteoclastogenesis and decreasing osteoclast apoptosis, thereby leading to increased bone resorption (Figure 1).
Positive_regulation (increased) of Transcription (transcription) of RANK-L in osteoclast associated with hypercalcemia and apoptosis
1) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.50 Pain Relevance 0

General Comments

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