INT339823

Context Info Confidence 0.29 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.55 Pain Relevance 0

cytoplasm (MAPK1, SRP72) cytosol (MAPK1, SRP72) nucleoplasm (MAPK1) mitochondrion (MAPK1) DNA binding (MAPK1) microtubule organizing center (MAPK1)

MAPK1 (Homo sapiens) SRP72 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 12 39.36 tolerance 14 5.00 rheumatoid arthritis 6 5.00 cytokine 4 5.00 Sicca syndrome 4 5.00 Osteoarthritis 4 5.00 Inflammatory mediators 2 5.00 IPN 2 5.00 Arthritis 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 16 93.84 INFLAMMATION 10 39.36 Dermatomyositis 18 5.00 Rheumatic Diseases 10 5.00 Rheumatoid Arthritis 6 5.00 Arthritis 4 5.00 Systemic Lupus Erythematosus 4 5.00 Autoimmune Disease 4 5.00 Syndrome 4 5.00 Osteoarthritis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because ERK1/2 and p38 MAPK inhibitors reduced SRP72 protein expression in rhIL-1?

ERK1/2 Negative_regulation (reduced) of Gene_expression (expression) of SRP72 protein

1) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.28 Pain Relevance 0

Because ERK1/2 and p38 MAPK inhibitors reduced SRP72 protein expression in rhIL-1?

p38 MAPK Negative_regulation (reduced) of Gene_expression (expression) of SRP72 protein

2) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.28 Pain Relevance 0

General Comments

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