INT339847

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 20
Disease Relevance 3.30
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SRP72) nucleolus (SRP72) plasma membrane (SRP72)
translation (SRP72) cytoplasm (SRP72)
Anatomy Link Frequency
nucleus 1
effector T cells 1
SRP72 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 120 89.04 High High
Osteoarthritis 40 87.92 High High
rheumatoid arthritis 60 87.16 High High
Inflammatory mediators 20 80.48 Quite High
cytokine 40 79.24 Quite High
tolerance 140 77.00 Quite High
imagery 20 67.76 Quite High
Sicca syndrome 40 64.16 Quite High
IPN 20 5.00 Very Low Very Low Very Low
Arthritis 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 160 98.76 Very High Very High Very High
Autoimmune Disease 40 94.16 High High
Dermatomyositis 180 93.20 High High
Cancer 20 92.32 High High
Arthritis 40 89.04 High High
Osteoarthritis 40 87.92 High High
Rheumatoid Arthritis 60 87.16 High High
INFLAMMATION 100 84.28 Quite High
Rheumatic Diseases 100 79.60 Quite High
Syndrome 40 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
was not able to show an increase of SRP72 expression at 120 and 240 min in the presence of MAPK inhibitors.
Gene_expression (expression) of SRP72
1) Confidence 0.77 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.09 Pain Relevance 0
The SRP72 protein expression was increased between 90 and 240 min of rhIL-1?
Gene_expression (expression) of SRP72 protein
2) Confidence 0.77 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
on SRP72 expression, Jurkat cells were cultured in complete RPMI 1640 medium without (control) or with 100 pg/ml rhIL-1?
Gene_expression (expression) of SRP72
3) Confidence 0.77 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.19 Pain Relevance 0
in Jurkat cells tested with MAPK inhibitors, showing no effect on mRNA expression of the SRP72 gene, which could explain that the SRP72 and all the components of the SRP complex are synthesized and assembled inside the nucleus to do their functions in the cytoplasm (2, 35).
Gene_expression (synthesized) of SRP72 in nucleus
4) Confidence 0.77 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.08 Pain Relevance 0
The aim of this study was to evaluate the pathways of phosphorylation and overexpression of the SRP72 polypeptide, using an in vitro model of Jurkat cells stimulated by rhIL-1?
Gene_expression (overexpression) of SRP72 polypeptide
5) Confidence 0.77 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.86 Pain Relevance 0.13
Results shown above indicated reduced SRP72 protein expression as well as reduced serine phosphorylation by MAPK inhibitors in rhIL-1?
Gene_expression (expression) of SRP72 protein
6) Confidence 0.77 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.25 Pain Relevance 0
Reduction of SRP72 protein expression by MAPK inhibitor was apparent at 120–240 min after culturing with both PD98059 (10 ?
Gene_expression (expression) of SRP72 protein
7) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
g/ml) to human SRP72 epitope mapping near the C terminus of SRP72 of human origin (Santa Cruz Biotechnology, 1:2500), human SRP54 (Sigma) (1:2500), which represents the nonphosphorylated SRP protein and human GAPDH (Syd Labs, Boston) (1:3000).
Gene_expression (mapping) of SRP72
8) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0.03
g/ml) to human SRP72 epitope mapping near the C terminus of SRP72 of human origin (Santa Cruz Biotechnology, 1:2500), human SRP54 (Sigma) (1:2500), which represents the nonphosphorylated SRP protein and human GAPDH (Syd Labs, Boston) (1:3000).
Gene_expression (mapping) of SRP72
9) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0.03
The reduction of SRP72 expression was confirmed by quantitative analysis as shown in RUA (Fig. 1, D and F).
Gene_expression (expression) of SRP72
10) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
SRP72 is a constitutive protein present in all eukaryotic organisms that is essential for survival; it is the unique organism that can survive after deletion of this SRP72 protein or other polypeptides of the SRP complex such as Saccharomyces cerevisiae (23), which demonstrates the importance of this protein inside the cellular mechanisms, mainly the translocation of secreted proteins.
Gene_expression (deletion) of SRP72 protein
11) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.06 Pain Relevance 0
The physiological and potential pathological implication of this phenomenon in production of autoantibodies to SRP72 is not known.
Gene_expression (production) of SRP72
12) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.16 Pain Relevance 0.08
Results shown above indicated reduced SRP72 protein expression as well as reduced serine phosphorylation by MAPK inhibitors in rhIL-1?
Gene_expression (above) of SRP72 protein
13) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.25 Pain Relevance 0
m SB202190 induced the maximum reduction of SRP72 expression (Fig. 2, A and C, respectively).
Gene_expression (expression) of SRP72
14) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
Both inhibitors induced a concentration-dependent reduction of SRP72 expression but did not affect SRP54 and GAPDH levels. 10 ?
Gene_expression (expression) of SRP72
15) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
In contrast, expression of SRP54 and the constitutive protein GAPDH was not changed, indicating specific inhibition of SRP72 expression by these MAPK inhibitors.


Gene_expression (expression) of SRP72
16) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
In contrast, JNK inhibitor SP600125 did not show any effect on expression of SRP72, SRP54, and GAPDH (Fig. 2, E and F).


Gene_expression (expression) of SRP72
17) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
Next, the effect of p38 inhibitors SB203580 (Fig. 2A) and SB202190 (Fig. 2C) on SRP72, SRP54, and GAPDH protein expression was examined by WB.
Gene_expression (expression) of SRP72
18) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
Because ERK1/2 and p38 MAPK inhibitors reduced SRP72 protein expression in rhIL-1?
Gene_expression (expression) of SRP72 protein
19) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.22 Pain Relevance 0
The aim of this work was to explore the phosphorylation status and expression of SRP72 autoantigen, using an in vitro model, previously reported by our group (17), on Jurkat cells that offer an excellent substrate to test models of autoimmune diseases because they are a stable tumor cell line capable of producing human IL-2, which stimulates the long term in vitro proliferation of antigenic specific effector T cells and enhances mitogenic properties; also they offer various antigen and effector specificities.
Gene_expression (expression) of SRP72 in effector T cells associated with autoimmune disease and cancer
20) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 1.14 Pain Relevance 0.37

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