INT339858

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SRP72) nucleolus (SRP72) plasma membrane (SRP72)
translation (SRP72) cytoplasm (SRP72)
Anatomy Link Frequency
nucleus 1
SRP72 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 72.64 Quite High
Sicca syndrome 4 35.36 Quite Low
tolerance 14 30.40 Quite Low
Osteoarthritis 4 13.44 Low Low
rheumatoid arthritis 6 12.68 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 16 80.44 Quite High
INFLAMMATION 10 72.64 Quite High
Syndrome 4 35.36 Quite Low
Systemic Lupus Erythematosus 4 34.52 Quite Low
Dermatomyositis 18 24.56 Low Low
Polymyositis 2 24.28 Low Low
Disease 2 19.04 Low Low
Osteoarthritis 4 13.44 Low Low
Rheumatoid Arthritis 6 12.68 Low Low
Rheumatic Diseases 10 11.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in Jurkat cells tested with MAPK inhibitors, showing no effect on mRNA expression of the SRP72 gene, which could explain that the SRP72 and all the components of the SRP complex are synthesized and assembled inside the nucleus to do their functions in the cytoplasm (2, 35).
Transcription (expression) of SRP72 in nucleus
1) Confidence 0.71 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.08 Pain Relevance 0
The results did not show significant changes on the mRNA expression of SRP72 mRNA after the treatment with these inhibitors, suggesting that the reduction of SRP72 protein expression is not mediated by down-regulation of SRP72 mRNA.



Transcription (expression) of SRP72
2) Confidence 0.53 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.26 Pain Relevance 0.07

General Comments

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