INT33993

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Context Info
Confidence 0.11
First Reported 1986
Last Reported 1995
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.74
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neutrophils 4
IGKV1D-39 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 46 99.76 Very High Very High Very High
Potency 3 99.62 Very High Very High Very High
opioid receptor 6 93.80 High High
agonist 6 93.00 High High
Opioid 2 92.80 High High
antagonist 2 92.24 High High
narcan 2 91.36 High High
Disease Link Frequency Relevance Heat
Disease 3 99.64 Very High Very High Very High
Adult Respiratory Distress Syndrome 6 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aminopeptidase inhibition by bestatin did not influence O2- release from MENK treated PMNs.
Neg (not) Regulation (influence) of Localization (release) of O2 associated with enkephalin
1) Confidence 0.11 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.21
In lower MENK concentrations, where MENK alone had no effect on O2- release, inhibition of enkephalinase by thiorphan significantly increased O2- production, while in higher concentrations, where MENK alone was effective, inhibition of enkephalinase had no effect.
Neg (no) Regulation (effect) of Localization (release) of O2 associated with enkephalin
2) Confidence 0.11 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.11
There was no correlation between the potency of the inhibitory effect on O-2 release and the effect of these agents on the binding of [3H] FMLP to human neutrophils.
Regulation (effect) of Localization (release) of O-2 in neutrophils associated with potency
3) Confidence 0.09 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.22 Pain Relevance 0.65
There was no correlation between the potency of the inhibitory effect on O-2 release and the effect of these agents on the binding of [3H] FMLP to human neutrophils.
Regulation (effect) of Localization (release) of O-2 in neutrophils associated with potency
4) Confidence 0.09 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.22 Pain Relevance 0.65
Control of the release of O-2 may prove beneficial.
Regulation (Control) of Localization (release) of O-2
5) Confidence 0.05 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.30 Pain Relevance 0.57

General Comments

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