INT33993

Context Info Confidence 0.11 First Reported 1986 Last Reported 1995 Negated 2 Speculated 0 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 0.74 Pain Relevance 4.18

Anatomy Link Frequency neutrophils 4 IGKV1D-39 (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 46 99.76 Potency 3 99.62 opioid receptor 6 93.80 agonist 6 93.00 Opioid 2 92.80 antagonist 2 92.24 narcan 2 91.36

Disease Link Frequency Relevance Heat Disease 3 99.64 Adult Respiratory Distress Syndrome 6 98.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Aminopeptidase inhibition by bestatin did not influence O2- release from MENK treated PMNs.

Neg (not) Regulation (influence) of Localization (release) of O2 associated with enkephalin

1) Confidence 0.11 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.21

In lower MENK concentrations, where MENK alone had no effect on O2- release, inhibition of enkephalinase by thiorphan significantly increased O2- production, while in higher concentrations, where MENK alone was effective, inhibition of enkephalinase had no effect.

Neg (no) Regulation (effect) of Localization (release) of O2 associated with enkephalin

2) Confidence 0.11 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.11

There was no correlation between the potency of the inhibitory effect on O-2 release and the effect of these agents on the binding of [3H] FMLP to human neutrophils.

Regulation (effect) of Localization (release) of O-2 in neutrophils associated with potency

3) Confidence 0.09 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.22 Pain Relevance 0.65

There was no correlation between the potency of the inhibitory effect on O-2 release and the effect of these agents on the binding of [3H] FMLP to human neutrophils.

Regulation (effect) of Localization (release) of O-2 in neutrophils associated with potency

4) Confidence 0.09 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.22 Pain Relevance 0.65

Control of the release of O-2 may prove beneficial.

Regulation (Control) of Localization (release) of O-2

5) Confidence 0.05 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.30 Pain Relevance 0.57

General Comments

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