INT339942

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (DPP4) extracellular region (DPP4) cell adhesion (DPP4)
Golgi apparatus (DPP4) endoplasmic reticulum (DPP4) plasma membrane (DPP4)
DPP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 5 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 1 55.84 Quite High
Dyslipidemia /

Combined Dyslipidemia

1 54.60 Quite High
Hyperlipidemia 2 53.40 Quite High
Hypertension 2 52.28 Quite High
Diabetes Mellitus 55 51.72 Quite High
Death 1 34.44 Quite Low
Myocardial Infarction 1 33.92 Quite Low
Stroke 1 33.00 Quite Low
Renal Insufficiency 2 6.88 Low Low
Disorders Of Creatine Metabolism 1 5.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, saxagliptin is not expected to alter the metabolic clearance of coadministered drugs that are metabolized by these enzymes.2 Saxagliptin metabolism is primarily mediated by CYP3A4/5 and 5-hydroxy saxagliptin, a major metabolite of saxagliptin, also a DPP-4 inhibitor.
Negative_regulation (metabolite) of Negative_regulation (inhibitor) of DPP-4
1) Confidence 0.33 Published 2010 Journal Core Evidence Section Body Doc Link PMC2963920 Disease Relevance 0.21 Pain Relevance 0

General Comments

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