INT33996

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Context Info
Confidence 0.53
First Reported 1984
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.34
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
NG108-15 2
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 23 100.00 Very High Very High Very High
narcan 20 99.84 Very High Very High Very High
withdrawal 1 99.60 Very High Very High Very High
medulla 1 91.76 High High
agonist 2 77.96 Quite High
cva 3 77.92 Quite High
antagonist 2 75.44 Quite High
Endogenous opioid 2 69.52 Quite High
Enkephalin 1 62.24 Quite High
Opioid 1 53.36 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 4 96.12 Very High Very High Very High
Eating Disorder 6 95.56 Very High Very High Very High
Hemorrhagic Shock 4 95.44 Very High Very High Very High
Reprotox - General 1 3 92.96 High High
Neuroblastoma 3 91.32 High High
Glioma 1 52.92 Quite High
Pressure Volume 2 Under Development 1 41.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Central opiate receptor blockade was induced by 10 micrograms/kg intracerebroventricularly (i.c.v.) injected naloxone at the 60th min of the bleeding period.
Positive_regulation (induced) of Negative_regulation (blockade) of opiate receptor associated with narcan, hemorrhage and opiate
1) Confidence 0.53 Published 1997 Journal Shock Section Abstract Doc Link 9110415 Disease Relevance 0.44 Pain Relevance 0.65
General opiate receptor blockade was induced by intracerebroventricularly (i.c.v) injected naloxone.
Positive_regulation (induced) of Negative_regulation (blockade) of opiate receptor associated with narcan and opiate
2) Confidence 0.28 Published 1997 Journal Pflugers Arch. Section Abstract Doc Link 9190560 Disease Relevance 0.08 Pain Relevance 0.54
The C6BU-1 parent of the NG108-15 hybrid showed poor specific binding of all ligands examined. dBcAMP was very potent in inducing opiate receptor site down-regulation of NCB-20 cells, with an ED50 after 4 days treatment of 8 microM.
Positive_regulation (inducing) of Negative_regulation (down-regulation) of opiate receptor in NG108-15 associated with opiate
3) Confidence 0.16 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3023808 Disease Relevance 0.25 Pain Relevance 0.67
In conclusion, the increase in LH release after opiate receptor blockade by naloxone suggests that endogenous opiates may play a role in the mechanism of inhibited LH secretion at least, in the majority of those women with anorexia nervosa in whom amenorrhea preceded wt loss.
Positive_regulation (increase) of Negative_regulation (blockade) of opiate receptor associated with narcan, opiate, reprotox - general 1 and eating disorder
4) Confidence 0.01 Published 1984 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6086696 Disease Relevance 0.58 Pain Relevance 0.82

General Comments

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