INT339991

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Context Info
Confidence 0.34
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1)
nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)
Anatomy Link Frequency
nucleus 1
SIRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 2 62.56 Quite High
Chronic pancreatitis 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fungal Infection 2 80.24 Quite High
Thyroid Neoplasm 4 72.96 Quite High
Cancer 90 50.00 Quite Low
Disease 8 50.00 Quite Low
Metastasis 8 8.76 Low Low
Pancreatic Cancer 48 6.92 Low Low
Apoptosis 38 5.00 Very Low Very Low Very Low
Death 28 5.00 Very Low Very Low Very Low
Adenocarcinoma 20 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas three SIRT proteins (SIRT1, SIRT6, and SIRT7) are nuclear localized, SIRT3, SIRT4, and SIRT5 are localized in the mitochondria and SIRT2 is a cytoplasmic protein [8].
Localization (localized) of SIRT1
1) Confidence 0.34 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.15 Pain Relevance 0.03
While Class II HDACs are able to shuttle in and out of the nucleus, the Class III sirtuin family (SIRT1-7) has a different localization.
Localization (localization) of SIRT1-7 in nucleus
2) Confidence 0.34 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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