INT3400

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Context Info
Confidence 0.68
First Reported 1978
Last Reported 2011
Negated 2
Speculated 5
Reported most in Abstract
Documents 57
Total Number 61
Disease Relevance 36.90
Pain Relevance 16.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skin 3
Heart 3
lymph node 1
AV node 1
epithelium 1
pr (Mus musculus)
Pain Link Frequency Relevance Heat
Oxycodone 500 100.00 Very High Very High Very High
narcan 318 100.00 Very High Very High Very High
backache 120 99.80 Very High Very High Very High
Serotonin 7 99.80 Very High Very High Very High
Antinociceptive 1 99.60 Very High Very High Very High
Migraine 89 99.46 Very High Very High Very High
anesthesia 32 99.12 Very High Very High Very High
alcohol 14 99.04 Very High Very High Very High
Triptan 164 98.40 Very High Very High Very High
imagery 243 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 407 99.98 Very High Very High Very High
Nicotine Addiction 16 99.98 Very High Very High Very High
Cancer 747 99.90 Very High Very High Very High
Metastasis 160 99.90 Very High Very High Very High
Low Back Pain 120 99.80 Very High Very High Very High
Migraine Disorders 94 99.46 Very High Very High Very High
Nociception 1 99.28 Very High Very High Very High
Acanthamoeba Keratitis 5 99.16 Very High Very High Very High
Pressure Volume 2 Under Development 13 98.86 Very High Very High Very High
Meningoencephalitis 6 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to sodium CMS, the protonated CMS provided a longer release time which increases with the increase of PR.
Positive_regulation (increase) of PR
1) Confidence 0.68 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20435114 Disease Relevance 0 Pain Relevance 0.09
Heart rate was slightly reduced and this resulted in a small increase in the PR interval and a prolongation of the QT interval of the lead II surface electrocardiogram.
Positive_regulation (increase) of PR in Heart
2) Confidence 0.46 Published 1978 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 736686 Disease Relevance 0 Pain Relevance 0.81
The PR interval was increased from 163.5 to 174.9 ms for verapamil vs 160.3 to 164.4 ms for propranolol.
Positive_regulation (increased) of PR
3) Confidence 0.46 Published 1986 Journal JAMA Section Abstract Doc Link 3531560 Disease Relevance 1.10 Pain Relevance 0.09
Twenty-four patients had isolated abnormal PR, but only six patients improved with antireflux therapy.
Positive_regulation (isolated) of PR
4) Confidence 0.45 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9398798 Disease Relevance 0.44 Pain Relevance 0.07
The following findings were made: (1) Baseline and follow-up prevalence of a prolonged PR (greater than or equal to 0.22 s) was identical (5.3 vs. 5.4%). (2) Only 60% of restudied men with a prolonged PR also had prolonged PR at follow-up. (3) Only 1 of 98 with a prolonged baseline PR had a more advanced AV block at follow-up, whereas an additional 4 had conditions which might influence the AV node (1 Bechterew's disease and 3 mild aortic valve stenosis). (4) The incidence of all CHD events found during the follow-up study (CHD deaths, myocardial infarction, angina pectoris, and pathologic exercise ECGs) was moderately but significantly lower in men with a prolonged PR than among men with a PR less than or equal to 0.21 s.
Positive_regulation (prolonged) of PR in AV node associated with angina, coronary artery disease, cardiac stenosis, disease and myocardial infarction
5) Confidence 0.40 Published 1984 Journal Clin Cardiol Section Abstract Doc Link 6705291 Disease Relevance 0.84 Pain Relevance 0.09
The prevalence ratio (PR) of reporting acute LBP was also found to increase as a function of the number of daily lifts/transfers performed (PR: 1.4; 95% CI: 1.27 to 1.70).
Positive_regulation (increase) of PR
6) Confidence 0.39 Published 2008 Journal Spine Section Body Doc Link 18317200 Disease Relevance 0 Pain Relevance 0
A PR and a DR were elicited in 20 patients (Group PR) and 63 patients (Group DR), respectively.
Positive_regulation (elicited) of PR
7) Confidence 0.32 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2881522 Disease Relevance 0.15 Pain Relevance 0.39
A PR and a DR were elicited in 20 patients (Group PR) and 63 patients (Group DR), respectively.
Positive_regulation (elicited) of PR
8) Confidence 0.32 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2881522 Disease Relevance 0.15 Pain Relevance 0.39
Transient and asymptomatic ECG changes (small mean increases in PR interval and QRS complex duration versus baseline) were noted in several subjects at 1 to 2 hours after infusion at doses > or = 3.0 mg/kg.
Positive_regulation (increases) of PR
9) Confidence 0.30 Published 1995 Journal J Clin Pharmacol Section Abstract Doc Link 7560251 Disease Relevance 0.46 Pain Relevance 0.17
Multivariate mixed-effects analyses revealed that (a) the PDR increased significantly in peak amplitude as stimulus intensity increased, (b) EP peaks at 150 and 250 ms differed significantly in both amplitude and latency across stimulus intensity, and (c) PR increased significantly with increasing stimulus intensity.
Positive_regulation (increased) of PR
10) Confidence 0.29 Published 1999 Journal Psychophysiology Section Abstract Doc Link 10098379 Disease Relevance 0.40 Pain Relevance 0.24
The alltogether 125 cycles (mean 4 cycles per patient) resulted in 43% PR (n = 12), 1 CR (3%), 255 MR, 11% SD and 18% PD in the imaging methods and 20% CR, 60% PR, 4% MR and 12% SD in the course of the relevant tumor markers.
Positive_regulation (resulted) of PR associated with cancer and imagery
11) Confidence 0.24 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10470175 Disease Relevance 0.86 Pain Relevance 0.21
Small but significant increases in heart rate and prolonged PR interval were noted with both drugs.
Positive_regulation (increases) of PR in heart
12) Confidence 0.22 Published 1984 Journal J Clin Psychiatry Section Abstract Doc Link 6208185 Disease Relevance 0.57 Pain Relevance 0.16
In this study, the genotypes of 14 Acanthamoeba isolates, each from a patient with AK, were identified according to the highly variable DF3 region in the 18S rRNA gene at Shandong Eye Institute, PR China, from 2000 to 2009, and the clinical characteristics of these patients were analysed.
Positive_regulation (variable) of PR in Eye associated with acanthamoeba keratitis and meningoencephalitis
13) Confidence 0.21 Published 2010 Journal J. Med. Microbiol. Section Abstract Doc Link 20056772 Disease Relevance 1.12 Pain Relevance 0.07
RESULTS: Of 73 study participants, 30 women underwent PR; 43 women did not (no PR).
Positive_regulation (underwent) of PR
14) Confidence 0.20 Published 2007 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 17618777 Disease Relevance 0.08 Pain Relevance 0
This substance may, however, occasionally result in a "paradoxical reaction" (PR) characterized by agitated excitement, mental confusion, and uncooperativeness.
Spec (may) Positive_regulation (result) of PR associated with confusion
15) Confidence 0.20 Published 1987 Journal Anaesthesist Section Abstract Doc Link 3592209 Disease Relevance 0.35 Pain Relevance 0.31
Patient global assessment of treatment efficacy improved with increasing naloxone PR dose.
Positive_regulation (increasing) of PR associated with narcan
16) Confidence 0.18 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2658020 Disease Relevance 0.09 Pain Relevance 0.28
The study also indicates that increased naloxone PR dose (10, 20 or 40 mg/day) is associated with superior ratings of global assessment of efficacy and preference for treatment.
Positive_regulation (increased) of PR in superior associated with narcan
17) Confidence 0.17 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2658020 Disease Relevance 0.89 Pain Relevance 0.86
Detailed characterization of the electrical activity of KO hearts revealed no difference in atrial depolarization, so that we can exclude slowed atrial conduction as a reason for the delayed AV conduction (increased PR interval).
Positive_regulation (increased) of PR in hearts associated with targeted disruption
18) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.54 Pain Relevance 0
Our laboratory previously used a series of keratin-driven, RU486-inducible Cre recombinase-progesterone receptor (PR) fusion proteins for genetic manipulation in the skin and oral epithelium 20, 21.
Positive_regulation (inducible) of PR in oral epithelium
19) Confidence 0.12 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2815352 Disease Relevance 0.38 Pain Relevance 0
A small increase of
               PR time in ECG was noted that did not differ across cohorts. 
Positive_regulation (increase) of PR
20) Confidence 0.11 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2754090 Disease Relevance 0.34 Pain Relevance 0.25

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