INT34007

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Context Info
Confidence 0.22
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.30
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Eno2) plasma membrane (Eno2) intracellular (Eno2)
cytoplasm (Eno2)
Anatomy Link Frequency
neuron 3
sustentacular cells 1
autonomic 1
Eno2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 2 96.64 Very High Very High Very High
Nucleus accumbens 1 95.04 Very High Very High Very High
Serotonin 4 93.84 High High
Enkephalin 4 92.80 High High
amygdala 1 91.00 High High
Hippocampus 1 89.08 High High
abdominal pain 1 86.32 High High
Opioid 1 85.44 High High
anticonvulsant 1 85.20 High High
Central nervous system 2 79.80 Quite High
Disease Link Frequency Relevance Heat
Sarcoma 6 99.92 Very High Very High Very High
Cancer 51 99.00 Very High Very High Very High
Granular Cell Tumor 33 98.60 Very High Very High Very High
Thyroid Neoplasm 2 95.68 Very High Very High Very High
Pheochromocytoma 1 94.72 High High
Metastasis 10 91.80 High High
Neurilemmoma 13 91.72 High High
Rhinitis 1 88.28 High High
Abdominal Pain 1 86.32 High High
Anxiety Disorder 1 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PRAX-1 mRNA expression was largely neuronal; it colocalized with neuron-specific enolase but not glial fibrillary acidic protein.
neuron-specific enolase Binding (colocalized) of in neuron
1) Confidence 0.22 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435798 Disease Relevance 0.16 Pain Relevance 0.44
These cells in rats and guinea pigs displayed a concomitant immunoreactivity for NSE.
NSE Binding (immunoreactivity) of
2) Confidence 0.08 Published 1993 Journal Arch. Histol. Cytol. Section Abstract Doc Link 8129983 Disease Relevance 0 Pain Relevance 0.25
Immunohistochemical staining showed positive reactivity for neuron-specific enolase and chromogranin in all tumors studied but was negative for insulin, glucagon, and somatostatin.
neuron-specific enolase Binding (reactivity) of in neuron associated with cancer and somatostatin
3) Confidence 0.07 Published 1986 Journal Surgery Section Abstract Doc Link 3024343 Disease Relevance 0.86 Pain Relevance 0.13
Immunoreactivity for neuron-specific enolase (NSE) and calcitonin was present in all tumors.
neuron-specific enolase Binding (Immunoreactivity) of in neuron associated with cancer
4) Confidence 0.03 Published 1985 Journal Ultrastruct Pathol Section Abstract Doc Link 3901454 Disease Relevance 0.52 Pain Relevance 0.25
Positivity with neuron specific enolase, chromogranin and synaptophysin was not seen and S-100 staining was seen in tumor cells and not in sustentacular cells as noted in pheochromocytoma

Course

neuron specific enolase Binding (Positivity) of in sustentacular cells associated with cancer and pheochromocytoma
5) Confidence 0.03 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1828733 Disease Relevance 0.95 Pain Relevance 0
Positive reactivity with neuron specific enolase (NSE), S-100 protein, synaptophysin, and chromogranin A (proteins expressed by neurons from the autonomic nerve plexus) have also been reported and this support the histogenesis of GANTs from the autonomic plexus of Meissner or Auerbach [5].
neuron specific enolase Binding (reactivity) of in autonomic
6) Confidence 0.02 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1182401 Disease Relevance 0.81 Pain Relevance 0

General Comments

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