INT34008

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.97
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
plasma 4
leg 2
Tbxa2r (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 99.76 Very High Very High Very High
Angina 15 99.50 Very High Very High Very High
agonist 20 98.60 Very High Very High Very High
Spinal cord 6 89.44 High High
Restless leg syndrome 3 75.00 Quite High
anesthesia 1 73.68 Quite High
Kinase C 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 99.76 Very High Very High Very High
Cv General 3 Under Development 15 99.50 Very High Very High Very High
Leg Ulcer 1 99.48 Very High Very High Very High
Injury 2 99.08 Very High Very High Very High
Increased Venous Pressure Under Development 9 98.52 Very High Very High Very High
Frailty 4 89.92 High High
INFLAMMATION 1 89.76 High High
Spinal Cord Compression 1 79.12 Quite High
Stress 16 50.00 Quite Low
Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with severe atherosclerosis of the lower limbs, characterized by leg ulcers and rest pain, the basal formation of TxA2 and prostacyclin (PGI2) is increased.
Positive_regulation (increased) of TxA2 Binding (formation) of in leg associated with pain, leg ulcer and increased venous pressure under development
1) Confidence 0.42 Published 1988 Journal Clin Physiol Section Abstract Doc Link 3402185 Disease Relevance 0.53 Pain Relevance 0.24
Present results indicate that in platelets from anginal patients phospholipid fatty acid composition is at least in part independent of plasma composition and that in active angina there are modifications leading to increased TxA2 formation and possibly contributing to the occurrence of ischemic attacks.
Positive_regulation (increased) of TxA2 Binding (formation) of in plasma associated with angina
2) Confidence 0.40 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3024352 Disease Relevance 0.47 Pain Relevance 0.47
Present results indicate that in platelets from anginal patients phospholipid fatty acid composition is at least in part independent of plasma composition and that in active angina there are modifications leading to increased TxA2 formation and possibly contributing to the occurrence of ischemic attacks.
Positive_regulation (leading) of TxA2 Binding (formation) of in plasma associated with angina
3) Confidence 0.40 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3024352 Disease Relevance 0.47 Pain Relevance 0.47
H2O2 exposure attenuates ligand-induced internalization of the thromboxane receptor
Positive_regulation (induced) of thromboxane receptor Binding (internalization) of
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0.05
However, injury also triggers the immediate calcium-mediated activation of phospholipase A2 (PLA2), the release of arachidonic acid, and the enzymatic formation of potentially deleterious prostaglandins (PGE2 alpha, PGE2), thromboxane A2 (TXA2), and leukotrienes (LTs).
Positive_regulation (activation) of TXA2 Binding (formation) of associated with injury
5) Confidence 0.17 Published 1995 Journal J. Neurotrauma Section Abstract Doc Link 7473799 Disease Relevance 0.50 Pain Relevance 0.24

General Comments

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