INT340086

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tgfb1, Cndp2) enzyme binding (Tgfb1) cytosol (Cndp2)
cell proliferation (Tgfb1) peptidase activity (Cndp2) extracellular space (Tgfb1)
Anatomy Link Frequency
vesicles 1
Tgfb1 (Mus musculus)
Cndp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 17 50.00 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 2 75.28 Quite High
Tetraploidy 1 67.68 Quite High
Apoptosis 30 66.36 Quite High
Aging 4 63.12 Quite High
Cancer 3 58.00 Quite High
INFLAMMATION 20 50.00 Quite Low
Stress 12 50.00 Quite Low
Necrosis 1 15.32 Low Low
Death 3 5.00 Very Low Very Low Very Low
Staphylococcus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed upregulation of MMP2 has been reported previously in involuting bovine mammary61 and agrees with the demonstrated effect of the protein on mammary tissue structure during involution.42 CTSC is an exopeptidase that can be found intracellularly in lysosomes or in exocytic vesicles and it is involved in the activation of proteinases in immune cells.62 FSTL3 acts through its binding to members of the TGFB superfamily such as activin and it also has an NF-kappaB response element that allows for TNF to upregulate its expression.63 Furthermore, TGFB1 potentiates the effect of TNF on FSTL3 expression through Smad proteins.
TGFB Binding (binding) of peptidase in vesicles
1) Confidence 0.04 Published 2010 Journal Bioinform Biol Insights Section Body Doc Link PMC2964046 Disease Relevance 0.38 Pain Relevance 0

General Comments

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