INT3401

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Context Info
Confidence 0.69
First Reported 1978
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 22
Total Number 26
Disease Relevance 16.33
Pain Relevance 7.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hp) extracellular region (Hp) Golgi apparatus (Hp)
endoplasmic reticulum (Hp) response to stress (Hp)
Anatomy Link Frequency
plasma 2
hepatocytes 1
heart 1
body 1
Hp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 7 100.00 Very High Very High Very High
Pain 18 99.80 Very High Very High Very High
abdominal pain 11 99.80 Very High Very High Very High
tail-flick 4 99.80 Very High Very High Very High
Chronic pancreatitis 10 99.60 Very High Very High Very High
Cluster headache 16 99.20 Very High Very High Very High
Inflammation 55 99.16 Very High Very High Very High
Bile 4 99.04 Very High Very High Very High
Arthritis 10 98.96 Very High Very High Very High
Angina 3 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ulcers 11 100.00 Very High Very High Very High
Diabetes Mellitus 146 99.84 Very High Very High Very High
Pain 13 99.80 Very High Very High Very High
Abdominal Pain 11 99.80 Very High Very High Very High
Burns 44 99.68 Very High Very High Very High
Pancreatitis 10 99.60 Very High Very High Very High
Disease 8 99.50 Very High Very High Very High
Injury 47 99.48 Very High Very High Very High
Hemolysis 1 99.36 Very High Very High Very High
Cluster Headache 16 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the rat, intravenous injection of BCG induced an increase in complement activity, oxidative activity towards paraphenylenediamine and serum haptoglobin level.
Positive_regulation (increase) of haptoglobin
1) Confidence 0.69 Published 1978 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 736703 Disease Relevance 0.16 Pain Relevance 0.16
Up to the fifth day after the pain event an increase of the haptoglobin concentration could be established.
Positive_regulation (increase) of haptoglobin associated with pain
2) Confidence 0.68 Published 1981 Journal Z Gesamte Inn Med Section Abstract Doc Link 6805142 Disease Relevance 0.69 Pain Relevance 0.35
In a comparative group of five with chronic ischaemic heart diseases and angina pectoris syndrome under the same conditions of examination no increase of haptoglobin could be observed during the first five days after the pain event.
Neg (no) Positive_regulation (increase) of haptoglobin in heart associated with pain, angina, coronary artery disease and syndrome
3) Confidence 0.68 Published 1981 Journal Z Gesamte Inn Med Section Abstract Doc Link 6805142 Disease Relevance 0.72 Pain Relevance 0.37
These examination results correspond with the literary data, that in disease with tissue destruction increases of haptoglobin are to be observed.
Positive_regulation (increases) of haptoglobin associated with disease
4) Confidence 0.68 Published 1981 Journal Z Gesamte Inn Med Section Abstract Doc Link 6805142 Disease Relevance 0.77 Pain Relevance 0.34
There were no pathologically increased values for serum haptoglobin or orosomucoid in our 9 patients with chronic cluster headache, again significantly less than in our 43 patients with active episodic cluster headache, 51 percent of whom had pathologically increased values of haptoglobin or orosomucoid.
Positive_regulation (increased) of haptoglobin associated with cluster headache
5) Confidence 0.68 Published 1991 Journal Headache Section Abstract Doc Link 1720429 Disease Relevance 0.89 Pain Relevance 0.83
Temporarily captive animals exhibited a 3.2-fold increase in Hp concentrations during the first 4 wk of captivity, followed by a return to entry levels by week 5.
Positive_regulation (increase) of Hp
6) Confidence 0.57 Published 2007 Journal J. Wildl. Dis. Section Abstract Doc Link 17495310 Disease Relevance 0.26 Pain Relevance 0.10
Biochemistry findings at 24 h included elevated aspartate aminotransferase, alanine aminotransferase, and haptoglobin; at 14 days all values were within normal ranges.
Positive_regulation (elevated) of haptoglobin
7) Confidence 0.49 Published 2007 Journal Int. J. Toxicol. Section Abstract Doc Link 17963132 Disease Relevance 0.38 Pain Relevance 0.19
There were no pathologically increased values for serum haptoglobin or orosomucoid in our 9 patients with chronic cluster headache, again significantly less than in our 43 patients with active episodic cluster headache, 51 percent of whom had pathologically increased values of haptoglobin or orosomucoid.
Neg (no) Positive_regulation (increased) of haptoglobin associated with cluster headache
8) Confidence 0.49 Published 1991 Journal Headache Section Abstract Doc Link 1720429 Disease Relevance 0.83 Pain Relevance 0.78
It was found in our previous studies that the concentration of fucosylated haptoglobin had increased in the sera of patients with pancreatic cancer (PC) compared to those of other types of cancer and normal controls.
Positive_regulation (increased) of haptoglobin associated with cancer and pancreatic cancer
9) Confidence 0.45 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18214858 Disease Relevance 0.65 Pain Relevance 0.13
The increased biliary haptoglobin suggested some hemolysis, while the reduction in the free immunoglobulin A (IgA) secretory component showed an AsIII-related decreased protein transport across hepatocytes to bile.
Positive_regulation (increased) of haptoglobin in hepatocytes associated with bile and hemolysis
10) Confidence 0.36 Published 1989 Journal J. Biochem. Toxicol. Section Abstract Doc Link 2593134 Disease Relevance 0.10 Pain Relevance 0.28
The effect of adjuvant arthritis (AA) on the pattern of rat serum proteins includes the upregulation of haptoglobin, orosomucoid, alpha2-macroglobulin, serine protease inhibitor-3, thiostatin, alpha1-antitrypsin, C-reactive protein, and the downregulation of kallikrein-binding protein, alpha1-inhibitor III, apolipoprotein A-I, alpha2-HS-glycoprotein, albumin, apolipoprotein A-IV, transthyretin and transferrin.
Positive_regulation (upregulation) of haptoglobin associated with experimental arthritis, disorder of lipid metabolism and arthritis
11) Confidence 0.34 Published 2000 Journal Electrophoresis Section Abstract Doc Link 10892728 Disease Relevance 0.72 Pain Relevance 0.30
Serum haptoglobin was determined after anesthesia induction and after the last transfusion on the day of operation.
Spec (determined) Positive_regulation (induction) of Serum haptoglobin associated with anesthesia
12) Confidence 0.30 Published 1988 Journal Anaesthesist Section Abstract Doc Link 3218723 Disease Relevance 0.25 Pain Relevance 0.10
Concentrations of haptoglobin were significantly increased one day post-surgery, indicating the presence of a significant acute inflammatory response, and returned to pre-surgical concentrations by seven days.
Positive_regulation (increased) of haptoglobin associated with inflammatory response
13) Confidence 0.30 Published 2007 Journal Lab. Anim. Section Abstract Doc Link 17640462 Disease Relevance 0.72 Pain Relevance 0.81
There was also a significant increase in the level of acute phase proteins, haptoglobin as well as orosomucoid in the serum of burned animals on both 5th and 10th day of thermal burn (Table 2).
Positive_regulation (increase) of haptoglobin associated with burns
14) Confidence 0.23 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2533690 Disease Relevance 0.58 Pain Relevance 0
The activity of tissue myeloperoxidase, the tissue TNF-alpha level and the serum haptoglobin level was increased by intraplantar CFA injection.
Positive_regulation (increased) of haptoglobin
15) Confidence 0.22 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19540223 Disease Relevance 0.54 Pain Relevance 0.41
The acute phase proteins—haptoglobin and orosomucoid which were increased due to burn injury were found to be decreased significantly in 200 mg/kg body weight extract treated animals.
Positive_regulation (increased) of haptoglobin in body associated with body weight, burns and injury
16) Confidence 0.20 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2533690 Disease Relevance 1.12 Pain Relevance 0.08
After M injection the rats of both the experimental and control groups showed a significant increase of HP L and TF L as compared to the baseline level, but there was no difference in L between the groups.
Positive_regulation (increase) of HP L associated with tail-flick
17) Confidence 0.16 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 3191224 Disease Relevance 0 Pain Relevance 0.79
Confirmation experiments of haptoglobin, Hspa1b, Marcks, Gnat1, and Rcn did not reveal specific protein detection at the appropriate molecular weight with the antibodies tested.
Positive_regulation (experiments) of haptoglobin
18) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.06 Pain Relevance 0
Fgf2, haptoglobin, and IL-4 levels were elevated in diabetic animals, while IL-17 levels were significantly decreased in diabetic levels.
Positive_regulation (elevated) of haptoglobin associated with diabetes mellitus
19) Confidence 0.15 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.90 Pain Relevance 0.05
In conclusion, castration decreased IFN-gamma production, ADG, and ADFI and increased haptoglobin and fibrinogen, and these effects seemed to be independent of plasma cortisol concentrations.
Positive_regulation (increased) of haptoglobin in plasma
20) Confidence 0.14 Published 1997 Journal J. Anim. Sci. Section Abstract Doc Link 9110218 Disease Relevance 0 Pain Relevance 0

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