INT340177

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.24
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1a) extracellular space (Oxt) extracellular region (Oxt)
plasma membrane (Avpr1a) response to stress (Avpr1a) signal transducer activity (Avpr1a)
Anatomy Link Frequency
neural 1
Oxt (Mus musculus)
Avpr1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 5 94.00 High High
Inflammation 5 93.68 High High
antagonist 97 84.72 Quite High
imagery 10 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Potency 7 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 17 99.30 Very High Very High Very High
Myocardial Infarction 5 98.12 Very High Very High Very High
Sprains And Strains 12 94.68 High High
Dysmenorrhea 5 94.00 High High
INFLAMMATION 5 93.68 High High
Targeted Disruption 60 87.84 High High
Increased Venous Pressure Under Development 5 83.28 Quite High
Natriuresis 15 76.08 Quite High
Embryonal Carcinoma 115 70.36 Quite High
Infarction 5 62.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The specific neural substrate(s) vital for Avpr1b's role in aggression is not known, nor is the possible interaction between Avpr1a and Avpr1b (or Oxt and the Oxtr for that matter—see, Winslow et al. 2000) in vivo.
Oxt Binding (interaction) of Avpr1a in neural associated with aggression
1) Confidence 0.15 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.37 Pain Relevance 0.03
Some data suggest that OT-GKR binding to V1aR is functional.
OT Binding (binding) of V1aR
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0.07
MolDock software investigated the interaction of OT molecules with OTR and V1aR [48].
OT Binding (interaction) of V1aR
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.06 Pain Relevance 0
The results demonstrate that OT-GKR can interact with several sites in transmembrane domains 3, 4, 5 and 7 of V1aR.
OT Binding (interact) of V1aR
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0.03
The clinical application of OT-GKR in this pathology could be safe because of the specific interaction with OTR and V1aR, as described in the present study.
OT Binding (interaction) of V1aR
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.69 Pain Relevance 0.17
OT's acts on only one type of OT receptor (OTR), an integral membrane protein that is a member of the rhodopsin-type (class I) G protein-coupled receptor family, which includes arginine vasopressin (AVP) receptor subtypes (V1aR, V1bR and V2).
OT Binding (receptor) of V1aR
6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.13 Pain Relevance 0

General Comments

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