INT340179

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.53
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oxtr) extracellular space (Oxt) extracellular region (Oxt)
signal transducer activity (Oxtr) cytoplasm (Oxt)
Anatomy Link Frequency
P19 1
neural 1
Oxt (Mus musculus)
Oxtr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 9 93.68 High High
Dismenorea 9 93.28 High High
antagonist 178 53.48 Quite High
agonist 18 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
depression 16 5.00 Very Low Very Low Very Low
Potency 13 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 34 99.30 Very High Very High Very High
Myocardial Infarction 9 98.12 Very High Very High Very High
Sprains And Strains 24 94.68 High High
INFLAMMATION 9 93.68 High High
Dysmenorrhea 9 93.28 High High
Stress 160 88.00 High High
Targeted Disruption 120 87.84 High High
Increased Venous Pressure Under Development 9 82.56 Quite High
Embryonal Carcinoma 207 70.36 Quite High
Apoptosis 18 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of significant molecular differences between OT-GKR and OT, the question has been raised whether OT-GKR interacts with OTR binding sites.
OT Binding (interacts) of OTR
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.06 Pain Relevance 0
MolDock software investigated the interaction of OT molecules with OTR and V1aR [48].
OT Binding (interaction) of OTR
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.06 Pain Relevance 0
In the present experiments, we investigated whether OT-GKR exists in fetal and newborn rodent hearts, interacts with the OT receptors (OTR) and primes the generation of contracting cells expressing CM markers in P19 cells, a model for the study of early heart differentiation.


OT Binding (interacts) of OTR in P19
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0
The clinical application of OT-GKR in this pathology could be safe because of the specific interaction with OTR and V1aR, as described in the present study.
OT Binding (interaction) of OTR
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.68 Pain Relevance 0.17
OT's acts on only one type of OT receptor (OTR), an integral membrane protein that is a member of the rhodopsin-type (class I) G protein-coupled receptor family, which includes arginine vasopressin (AVP) receptor subtypes (V1aR, V1bR and V2).
OT Binding (receptor) of OTR
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.06 Pain Relevance 0
The recognition of Ile-3 by OTR seems to be specific for OT molecules, because this amino acid residue is absent in the cyclic part of the AVP molecule.
OT Binding (recognition) of OTR
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0
Because of significant molecular differences between OT-GKR and OT, the question has been raised whether OT-GKR interacts with OTR binding sites.
OT Binding (interacts) of OTR
7) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.07 Pain Relevance 0
Because of significant molecular differences between OT-GKR and OT, the question has been raised whether OT-GKR interacts with OTR binding sites.
OT Binding (interacts) of OTR
8) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.07 Pain Relevance 0
Docking analysis shows OT-GKR interaction with OTR
OT Binding (interaction) of OTR
9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.07 Pain Relevance 0
Arginine vasopressin (Avp) is a cyclic nonapeptide that exerts diverse biological effects through a number of receptors (R), three of which have been cloned to date in mammals; the vasopressin Avprla, Avprlb and Avpr2—Avp also binds to the structurally related oxytocin (Oxt) receptor (Oxtr) with high affinity.
Oxt Binding (binds) of Oxtr
10) Confidence 0.10 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.09 Pain Relevance 0
The specific neural substrate(s) vital for Avpr1b's role in aggression is not known, nor is the possible interaction between Avpr1a and Avpr1b (or Oxt and the Oxtr for that matter—see, Winslow et al. 2000) in vivo.
Oxt Binding (interaction) of Oxtr in neural associated with aggression
11) Confidence 0.10 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.37 Pain Relevance 0.03

General Comments

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