INT340189

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 5.16
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pttg1ip) nucleus (Pttg1ip) molecular_function (Pttg1ip)
cytoplasm (Pttg1ip)
Pttg1ip (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 352 99.64 Very High Very High Very High
medulla 165 93.96 High High
5HT 77 87.20 High High
Raphe 44 75.92 Quite High
Serotonin 66 58.00 Quite High
antidepressant 55 56.04 Quite High
Raphe magnus 22 18.08 Low Low
imagery 11 6.56 Low Low
depression 11 5.00 Very Low Very Low Very Low
Locus ceruleus 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 627 100.00 Very High Very High Very High
Sudden Infant Death Syndrome 66 5.00 Very Low Very Low Very Low
Targeted Disruption 55 5.00 Very Low Very Low Very Low
Syndrome 44 5.00 Very Low Very Low Very Low
Rare Diseases 33 5.00 Very Low Very Low Very Low
Death 22 5.00 Very Low Very Low Very Low
Hypoventilation 22 5.00 Very Low Very Low Very Low
Hypoxia 11 5.00 Very Low Very Low Very Low
Congenital Anomalies 11 5.00 Very Low Very Low Very Low
Hypercapnia 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant relationship was found between the PBf responses to acidosis and the control PBf either prior to (r?
Gene_expression (responses) of PBf associated with acidosis
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.52 Pain Relevance 0.17
Basic aspects of the fluoxetine abolition of the PBf response to acidosis
Gene_expression (response) of PBf associated with acidosis and fluoxetine
2) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.43 Pain Relevance 0.64
The 5 min period under aCSF(7.4) prior to any drug application was used to define the control PBf (100%) and the changes in PBf induced by application of the modified aCSF were expressed in % of control PBf.
Gene_expression (expressed) of PBf
3) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.38 Pain Relevance 0.32
No significant relationship was found between the PBf responses to acidosis and the control PBf either prior to (r?
Gene_expression (responses) of PBf associated with acidosis
4) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.53 Pain Relevance 0.17
When superfusion with aCSF(7.4) was resumed, the PBf recovered control values within two min.
Gene_expression (recovered) of PBf
5) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.57 Pain Relevance 0
The 5 min period under aCSF(7.4) prior to any drug application was used to define the control PBf (100%) and the changes in PBf induced by application of the modified aCSF were expressed in % of control PBf.
Gene_expression (expressed) of PBf
6) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.33 Pain Relevance 0.38
6) PBf under 5-HT (mean PBf response: 0.2±0.9 c.min?
Gene_expression (response) of PBf
7) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.48 Pain Relevance 0.17
6) PBf under 5-HT (mean PBf response: 0.2±0.9 c.min?
Gene_expression (response) of PBf
8) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.48 Pain Relevance 0.17
As five and ten min acidosis applications similarly affect the PBf, we speculate that the PBf response to acidosis we have analyzed reflects the integrated response of the whole medullary chemosensitive system rather than the solely response of superficial RTN/pFRG chemoreceptors.


Gene_expression (affect) of PBf associated with acidosis
9) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.37 Pain Relevance 0.53
In addition, no significant difference was observed between the PBf response to acidosis in preparations displaying the highest (22.7±2.4 c.min?
Gene_expression (response) of PBf associated with acidosis
10) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.53 Pain Relevance 0.17
No significant relationship was found between the PBf responses to acidosis and the control PBf either prior to (r?
Gene_expression (acidosis) of PBf associated with acidosis
11) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.53 Pain Relevance 0.12

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