INT340193

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 12.80
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pttg1ip) nucleus (Pttg1ip) molecular_function (Pttg1ip)
cytoplasm (Pttg1ip)
Anatomy Link Frequency
phrenic 1
Pttg1ip (Mus musculus)
Pain Link Frequency Relevance Heat
5HT 126 99.70 Very High Very High Very High
fluoxetine 576 99.04 Very High Very High Very High
medulla 270 77.28 Quite High
Raphe 72 67.56 Quite High
Raphe magnus 36 49.72 Quite Low
Serotonin 108 32.04 Quite Low
antidepressant 90 30.08 Quite Low
imagery 18 26.52 Quite Low
depression 18 5.00 Very Low Very Low Very Low
Locus ceruleus 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 1026 99.98 Very High Very High Very High
Sudden Infant Death Syndrome 108 5.00 Very Low Very Low Very Low
Targeted Disruption 90 5.00 Very Low Very Low Very Low
Syndrome 72 5.00 Very Low Very Low Very Low
Rare Diseases 54 5.00 Very Low Very Low Very Low
Death 36 5.00 Very Low Very Low Very Low
Hypoventilation 36 5.00 Very Low Very Low Very Low
Hypoxia 18 5.00 Very Low Very Low Very Low
Congenital Anomalies 18 5.00 Very Low Very Low Very Low
Hypercapnia 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Herein applying fluoxetine at weaker concentrations did not significantly increase the PBf but totally abolished the PBf response to acidosis.
Neg (not) Positive_regulation (increase) of PBf associated with acidosis and fluoxetine
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.47 Pain Relevance 0.58
On the whole sample of 18 preparations, acidosis always increased the PBf.
Positive_regulation (increased) of PBf associated with acidosis
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 1.01 Pain Relevance 0
No significant relationship was found between the PBf increment induced by acidosis at the 5th min and the control PBf prior to acidosis (r?
Positive_regulation (increment) of PBf associated with acidosis
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.95 Pain Relevance 0
1) using a student's paired t-test to compare the PBf during acidosis to the mean PBf calculated during the five min prior to the acidosis tests.
Positive_regulation (calculated) of PBf associated with acidosis
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.26 Pain Relevance 0.05
5) control PBf (mean PBf increment: 3.7±1.4 c.min?
Positive_regulation (increment) of PBf
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.97 Pain Relevance 0.09
Herein applying fluoxetine at weaker concentrations did not significantly increase the PBf but totally abolished the PBf response to acidosis.
Positive_regulation (response) of PBf associated with acidosis and fluoxetine
6) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.47 Pain Relevance 0.55
Therefore, acidosis increased the PBf in all the preparations, even when the control PBf was high.
Positive_regulation (increased) of PBf associated with acidosis
7) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 1.02 Pain Relevance 0.15
In addition, no significant difference was observed between the mean PBf increment induced by acidosis at the 5th min in preparations displaying the highest (13.1±0.6 c.min?
Positive_regulation (increment) of PBf associated with acidosis
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 1.08 Pain Relevance 0.03
Excess of 5HT abolishes the PBf response to acidosis
Positive_regulation (response) of PBf associated with acidosis and 5ht
9) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.84 Pain Relevance 0.28
In a second set of experiments, six other preparations were also subjected to aCSF(7.1) but the application was maintained for ten min instead of five min to know whether longer period of acidosis induced more marked changes in the PBf (Fig. 1C).
Spec (whether) Positive_regulation (induced) of PBf associated with acidosis
10) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.78 Pain Relevance 0
As five and ten min of acidosis similarly increased the PBf, data corresponding to the PBf changes induced by the first five min of acidosis in the two types of experiments (five and ten min of acidosis) were pooled together.
Positive_regulation (increased) of PBf associated with acidosis
11) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 1.02 Pain Relevance 0
Acidosis increases the PBf of en bloc medullary preparations
Positive_regulation (increases) of PBf associated with acidosis
12) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.34 Pain Relevance 0.03
5) control PBf (mean PBf increment: 3.7±1.4 c.min?
Positive_regulation (increment) of PBf
13) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.97 Pain Relevance 0.09
1, respectively; P>0.2).Then, exposure of preparations to exogenous 5-HT abolished the PBf response to acidosis, even when the PBf was moderately increased by 5-HT exposure.


Positive_regulation (increased) of PBf associated with acidosis
14) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.48 Pain Relevance 0.21
In medullary preparations of neonatal mice, acidosis increases the PBf by about 40% without affecting the phrenic burst amplitude, in agreement with previous reports in neonatal rats [30] and foetal mice [7].
Positive_regulation (increases) of PBf in phrenic associated with acidosis
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.55 Pain Relevance 0.19
The abolition of the PBf response by 5-HT applications was unlikely caused by the increased resting PBf since no significant relationship was found between the resting PBf and the magnitude of the PBf response to acidosis under normal aCSF as well as under aCSF containing 5-HT.
Positive_regulation (increased) of PBf associated with acidosis
16) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.44 Pain Relevance 0.48
As applications of fluoxetine at large concentration (100 µM) were reported to double the mean PBf [16], we used weaker concentrations to avoid marked increases of the resting PBf.
Positive_regulation (increases) of PBf associated with fluoxetine
17) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.69 Pain Relevance 0.65
Mimicking the fluoxetine-induced increase in 5-HT levels with exogenous 5-HT application significantly increased the PBf and also totally abolished the PBf response.
Positive_regulation (increased) of PBf associated with fluoxetine
18) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.46 Pain Relevance 0.52

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