INT340195

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 4.53
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pttg1ip) nucleus (Pttg1ip) molecular_function (Pttg1ip)
cytoplasm (Pttg1ip)
Anatomy Link Frequency
brainstem 1
Pttg1ip (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 224 98.32 Very High Very High Very High
medulla 105 98.18 Very High Very High Very High
Neurotransmitter 7 90.72 High High
5HT 49 87.20 High High
Raphe 28 80.44 Quite High
Locus ceruleus 7 75.92 Quite High
Neuronal excitability 7 45.48 Quite Low
Serotonin 42 38.12 Quite Low
antidepressant 35 36.16 Quite Low
imagery 7 10.32 Low Low
Disease Link Frequency Relevance Heat
Acidosis 399 99.90 Very High Very High Very High
Targeted Disruption 35 70.96 Quite High
Syndrome 28 46.48 Quite Low
Rare Diseases 21 45.52 Quite Low
Hypoventilation 14 30.32 Quite Low
Sudden Infant Death Syndrome 42 10.32 Low Low
Death 14 7.84 Low Low
Hypoxia 7 5.00 Very Low Very Low Very Low
Congenital Anomalies 7 5.00 Very Low Very Low Very Low
Hypercapnia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It had no significant effects on the mean PBf during the first min, weakly but significantly increased it from the second min (112±4%) and raised the PBf up to 137±6% of the control at the 5th min.
Neg (no) Regulation (effects) of PBf
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 1.01 Pain Relevance 0
5) control PBf (mean PBf increment: 3.7±1.4 c.min?
Regulation (control) of PBf
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.97 Pain Relevance 0.09
As shown in Fig. 1B, the mean PBF did not change in the first two min of acidosis, after which it significantly increased to reach 133±8% of the control PBf during the last min of acidosis.
Regulation (control) of PBf associated with acidosis
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.56 Pain Relevance 0
Therefore, acidosis increased the PBf in all the preparations, even when the control PBf was high.
Regulation (control) of PBf associated with acidosis
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.96 Pain Relevance 0.16
As in previous reports [15], [16], [24], [25], the figures present the mean PBf changes as % of the control PBf, whereas the statistical analysis of the changes in PBf was performed on absolute values (cycle per min, c.min?
Regulation (changes) of PBf
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.29 Pain Relevance 0.11
We therefore speculate that the fluoxetine-induced excess of 5-HT reduces the gap junction coupling between brainstem chemoreceptors and that a disorganized chemoreceptor drive to the RRG during acidosis may affect the PBf response.
Spec (may) Regulation (affect) of PBf in brainstem associated with medulla, acidosis and fluoxetine
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.36 Pain Relevance 0.52
As five and ten min acidosis applications similarly affect the PBf, we speculate that the PBf response to acidosis we have analyzed reflects the integrated response of the whole medullary chemosensitive system rather than the solely response of superficial RTN/pFRG chemoreceptors.


Regulation (affect) of PBf associated with acidosis
7) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.37 Pain Relevance 0.53

General Comments

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