INT340200

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Smyd5) cellular_component (Smyd5) biological_process (Smyd5)
Anatomy Link Frequency
RTN 1
Smyd5 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 12 99.20 Very High Very High Very High
fluoxetine 64 98.64 Very High Very High Very High
antidepressant 10 84.16 Quite High
5HT 14 76.88 Quite High
medulla 30 71.96 Quite High
Raphe 8 5.00 Very Low Very Low Very Low
Raphe magnus 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 100.00 Very High Very High Very High
Syndrome 8 100.00 Very High Very High Very High
Rare Diseases 6 100.00 Very High Very High Very High
Hypoventilation 4 100.00 Very High Very High Very High
Death 4 83.48 Quite High
Sudden Infant Death Syndrome 12 82.44 Quite High
Hypoxia 2 79.72 Quite High
Hypercapnia 2 61.12 Quite High
Acidosis 114 50.00 Quite Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RTN/pFRG neurons are severely depleted in transgenic mouse model of the Central Congenital Hypoventilation Syndrome, a rare disease defined by the lack of CO2/pH responsiveness and RRG automaticity during sleep [11].
Negative_regulation (depleted) of RRG in RTN associated with rare diseases, targeted disruption, syndrome and hypoventilation
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.51 Pain Relevance 0.08
Using en bloc medullary preparations where the isolated RRG still functions in vitro and responds to CO2/pH changes, we show that a pre-treatment with fluoxetine, a blocker of the serotonin transporter (SERT) and 5-HT re-uptake, abolishes the RRG responses to CO2/pH.
Negative_regulation (abolishes) of RRG associated with serotonin and fluoxetine
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.59 Pain Relevance 0.35

General Comments

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