INT340203

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.50
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Smyd5) cellular_component (Smyd5) biological_process (Smyd5)
Anatomy Link Frequency
brainstem 1
respiratory 1
Smyd5 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 60 100.00 Very High Very High Very High
Neurotransmitter 4 99.80 Very High Very High Very High
5HT 28 99.64 Very High Very High Very High
fluoxetine 128 99.42 Very High Very High Very High
Serotonin 24 91.00 High High
Neuronal excitability 4 80.64 Quite High
Locus ceruleus 4 80.32 Quite High
Raphe 16 78.24 Quite High
antidepressant 20 5.00 Very Low Very Low Very Low
Raphe magnus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 228 99.24 Very High Very High Very High
Hypercapnia 4 97.28 Very High Very High Very High
Targeted Disruption 20 85.36 High High
Rare Diseases 12 82.80 Quite High
Syndrome 16 82.24 Quite High
Hypoventilation 8 81.80 Quite High
Hypoxia 4 55.28 Quite High
Sudden Infant Death Syndrome 24 52.00 Quite High
Death 8 47.60 Quite Low
Congenital Anomalies 4 16.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the fluoxetine-induced excess of 5-HT may directly (via the 5-HT system) and indirectly (via other neurotransmitter systems) affect the RRG responsiveness to acidosis as well as the elaboration of the chemoreceptor drive.
Regulation (affect) of RRG associated with neurotransmitter, acidosis and fluoxetine
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.52 Pain Relevance 0.51
As recently reviewed, the 5-HT neurons are involved in respiratory function and dysfunction [14], they synaptically contact the RRG [15], modulate the activity of the maturing RRG [16], are intrinsically chemosensitive in vitro, are stimulated by hypercapnia in vivo, and their disruption alters the ventilatory response to CO2/pH changes [12], [17], [18].
Regulation (modulate) of RRG in respiratory associated with hypercapnia
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.78 Pain Relevance 0.10
An excess of endogenous 5-HT affects the expression of 5-HT1A receptors, the RRG modulation by 5-HT [36], [40] and may also affect non-5HT systems known to modulate the RRG such as the catecholaminergic system [41], [42].
Regulation (modulate) of RRG associated with 5ht
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.07 Pain Relevance 0.43
Nevertheless, fluoxetine blockade of 5-HT uptake may affect the 5-HT levels, the pH response of brainstem chemoreceptors and the RRG activity and responsiveness.
Spec (may) Regulation (affect) of RRG in brainstem associated with medulla and fluoxetine
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.13 Pain Relevance 0.29

General Comments

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