INT340209

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Frg1) nucleus (Frg1) ribosome biogenesis (Frg1)
Anatomy Link Frequency
RTN 1
Frg1 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 30 97.08 Very High Very High Very High
Raphe 8 95.48 Very High Very High Very High
Locus ceruleus 2 90.96 High High
fluoxetine 64 86.24 High High
5HT 14 79.16 Quite High
Serotonin 12 76.88 Quite High
Neurotransmitter 2 61.76 Quite High
Neuronal excitability 2 60.52 Quite High
antidepressant 10 5.00 Very Low Very Low Very Low
Raphe magnus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 99.84 Very High Very High Very High
Hypoventilation 4 97.88 Very High Very High Very High
Syndrome 8 97.24 Very High Very High Very High
Rare Diseases 6 96.76 Very High Very High Very High
Acidosis 114 73.20 Quite High
Hypercapnia 2 49.44 Quite Low
Hypoxia 2 10.16 Low Low
Sudden Infant Death Syndrome 12 6.88 Low Low
Death 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RTN/pFRG neurons are severely depleted in transgenic mouse model of the Central Congenital Hypoventilation Syndrome, a rare disease defined by the lack of CO2/pH responsiveness and RRG automaticity during sleep [11].
Negative_regulation (depleted) of pFRG in RTN associated with rare diseases, targeted disruption, syndrome and hypoventilation
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.39 Pain Relevance 0.07
Blockade of gap junctions reduces the in vivo RTN/pFRG chemosensitivity [48] and the in vitro resting PBf [49].
Negative_regulation (reduces) of pFRG
2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.13 Pain Relevance 0.53

General Comments

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