INT340265

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) response to stress (Tnfsf11)
Anatomy Link Frequency
osteoblast 1
Tnfsf11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 22 82.96 Quite High
nociceptor 3 80.72 Quite High
Pain 53 76.76 Quite High
Intractable pain 2 54.80 Quite High
imagery 30 50.00 Quite Low
antagonist 5 50.00 Quite Low
Potency 7 37.52 Quite Low
positron emission tomography 15 31.80 Quite Low
Breakthrough pain 5 21.24 Low Low
Analgesic 6 18.00 Low Low
Disease Link Frequency Relevance Heat
Osteoporosis 12 99.98 Very High Very High Very High
Cancer 95 98.70 Very High Very High Very High
Respiratory Syncytial Virus 116 94.00 High High
Hypercalcemia 16 86.32 High High
Bone Cancer 39 82.76 Quite High
Pain 60 76.76 Quite High
Disease 1 63.28 Quite High
Intractable Pain 2 54.80 Quite High
Aggression 3 53.24 Quite High
Embolism 1 49.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One-hour or 7-day treatment with PDM02 suppressed RANKL-induced nuclear translocation of NF-?
Localization (translocation) of RANKL
1) Confidence 0.30 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.44 Pain Relevance 0
The tumor releases osteoclast maturation factors or stimulates osteoblast secretion of RANKL and down-regulation of osteoprotegerin, resulting in dominant resorptive activity [9], [84], [85].
Localization (secretion) of RANKL in osteoblast associated with cancer and osteoporosis
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966439 Disease Relevance 1.21 Pain Relevance 0.44

General Comments

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