INT340294

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Context Info
Confidence 0.06
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.53
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Ea1 (Mus musculus)
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 164 100.00 Very High Very High Very High
tolerance 14 80.44 Quite High
Neuropeptide 4 19.24 Low Low
Central nervous system 2 13.72 Low Low
Spinal cord 2 12.48 Low Low
Acupuncture 20 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Fibrositis 2 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 52 98.92 Very High Very High Very High
Impaired Glucose Tolerance 6 80.44 Quite High
Stress 4 56.76 Quite High
Diabetes Mellitus 28 56.72 Quite High
Hyperglycemia 6 53.44 Quite High
Obesity 24 50.00 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 4 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study revealed that EA activated SIRT1, indicating that improved insulin resistance by EA may be attributed to enhanced SIRT1 expression.
EA Positive_regulation (activated) of SIRT1 associated with insulin resistance and electroacupuncture
1) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.40 Pain Relevance 0.39
EA significantly increased SIRT1 protein levels in db/db and db/m mice (Figure 2), but it produced no significant effect on SIRT1 mRNA levels (Figure 3(a)).
EA Positive_regulation (increased) of SIRT1 protein associated with electroacupuncture
2) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.14 Pain Relevance 0.44

General Comments

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