INT3403

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Context Info
Confidence 0.63
First Reported 1978
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 18.95
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (BCAR1) cytosol (BCAR1) signal transduction (BCAR1)
cell adhesion (BCAR1) plasma membrane (BCAR1) cell division (BCAR1)
Anatomy Link Frequency
blood 1
mitral valve 1
chromaffin cells 1
platelet 1
BCAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 21 100.00 Very High Very High Very High
Catecholamine 7 100.00 Very High Very High Very High
diclofenac 12 99.98 Very High Very High Very High
anesthesia 36 97.72 Very High Very High Very High
Nicotine 1 97.24 Very High Very High Very High
dexamethasone 6 95.92 Very High Very High Very High
Angina 15 94.92 High High
Neurotransmitter 10 94.72 High High
depression 19 92.44 High High
Enkephalin 8 86.36 High High
Disease Link Frequency Relevance Heat
Congenital Anomalies 291 100.00 Very High Very High Very High
Adhesions 94 100.00 Very High Very High Very High
Cerebellar Ataxia 74 100.00 Very High Very High Very High
Syndrome 69 100.00 Very High Very High Very High
Chromosome Aberrations 22 100.00 Very High Very High Very High
Cv General 3 Under Development 21 100.00 Very High Very High Very High
Hepatic Encephalopathy 4 99.90 Very High Very High Very High
Hodgkin's Disease 2 99.88 Very High Very High Very High
Hemorrhage 28 99.38 Very High Very High Very High
Anxiety Disorder 18 99.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A dose response increase in the level of CAs and Met-enk in bovine adrenal chromaffin cells was obtained with doses varying between 0 and 10(-6)M dexamethasone 18 hours after administration.
Positive_regulation (increase) of CAs in chromaffin cells associated with catecholamine and dexamethasone
1) Confidence 0.63 Published 1984 Journal Life Sci. Section Abstract Doc Link 6492996 Disease Relevance 0.24 Pain Relevance 0.80
At the evaluation of seven orally used sulfonamides, only two showed teratogenic potential, and they induced different CAs 30.
Positive_regulation (induced) of CAs associated with congenital anomalies
2) Confidence 0.61 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1168874 Disease Relevance 0.51 Pain Relevance 0.03
Second, many planned and wanted pregnancies are terminated due to the anxiety and fear created by the notion that nearly all drugs cause CAs 42.
Positive_regulation (cause) of CAs associated with congenital anomalies and anxiety disorder
3) Confidence 0.61 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1168874 Disease Relevance 1.40 Pain Relevance 0
The number of CAs induced by human teratogenic drugs is about 6 per 1,000 on the basis of Table 1 and 2 (Table 3).
Positive_regulation (induced) of CAs associated with congenital anomalies
4) Confidence 0.61 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1168874 Disease Relevance 2.03 Pain Relevance 0.05
Thus, it is necessary to know that before the first missed menstrual bleeding, environmental factors cannot induce CAs.
Positive_regulation (induce) of CAs associated with congenital anomalies and hemorrhage
5) Confidence 0.41 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1168874 Disease Relevance 0.85 Pain Relevance 0
The total proportion of CAs induced by drugs is less than 1 % in the database of the HCCSCA, if we calculate 65.27 per 1,000 total rate of CAs in Hungary 45.


Positive_regulation (induced) of CAs associated with congenital anomalies
6) Confidence 0.41 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1168874 Disease Relevance 1.43 Pain Relevance 0.08
Therefore we have to focus our analysis on specific CAs since teratogenic drugs induce specific CAs without affecting other CAs and overall rates.
Positive_regulation (induce) of CAs associated with congenital anomalies
7) Confidence 0.41 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1168874 Disease Relevance 1.79 Pain Relevance 0.04
The seemingly similar component CAs within multimalformed or syndromic cases are caused by chromosomal aberrations, gene mutations or teratogens 28.
Positive_regulation (caused) of CAs associated with chromosome aberrations and congenital anomalies
8) Confidence 0.41 Published 2005 Journal International Journal of Medical Sciences Section Body Doc Link PMC1168874 Disease Relevance 1.61 Pain Relevance 0.04
Thus, symptomatic CAS induced by ergonovine was absent in the majority of these 24 patients with idiopathic mitral valve prolapse syndrome.
Positive_regulation (induced) of CAS in mitral valve associated with mitral valve prolapse and cva
9) Confidence 0.40 Published 1978 Journal Cathet Cardiovasc Diagn Section Abstract Doc Link 737730 Disease Relevance 1.56 Pain Relevance 0.92
We suggest that hepatic encephalopathy may trigger CAS, although the significance of physostigmine in the treatment of hepatic encephalopathy remains to be addressed by controlled investigations.
Spec (may) Positive_regulation (trigger) of CAS associated with syndrome and hepatic encephalopathy
10) Confidence 0.39 Published 1999 Journal Eur J Anaesthesiol Section Abstract Doc Link 10101633 Disease Relevance 1.41 Pain Relevance 0.07
We were unable to identify p130 Cas in these samples by mass spectrometry, probably because of the relatively low abundance of this signaling molecule compared to cytoskeletal proteins such as CaD, myosin, alpha actinin and filamin.


Neg (unable) Positive_regulation (identify) of Cas
11) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.30 Pain Relevance 0
Removal rates of 26 and 56% were achieved for 4'-OH-DCF following CAS and MBR treatment, respectively.
Positive_regulation (following) of CAS associated with diclofenac
12) Confidence 0.26 Published 2008 Journal Anal. Chem. Section Abstract Doc Link 18821734 Disease Relevance 0.07 Pain Relevance 0.47
By using phosphotyrosine screening and mass spectrometry of stretched human myometrial samples, we identify 3 stretch-activated focal adhesion proteins, FAK, p130Cas, and alpha actinin.
Positive_regulation (activated) of p130Cas associated with adhesions
13) Confidence 0.23 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759504 Disease Relevance 0.43 Pain Relevance 0
CONCLUSIONS: These findings suggest that activation of 5HT(1B) receptor by SMT can induce CAS directly in patients with VA without platelet activation.
Positive_regulation (induce) of CAS in platelet
14) Confidence 0.22 Published 2007 Journal Int. J. Cardiol. Section Body Doc Link 16890312 Disease Relevance 0.13 Pain Relevance 0
With the increase in CAS procedures, it is important for endovascular surgeons and radiologists to take into consideration the possibility of abdominal wall hematoma in this situation.


Positive_regulation (increase) of CAS associated with hematoma
15) Confidence 0.18 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2780982 Disease Relevance 1.11 Pain Relevance 0.07
Inherited CAs
Positive_regulation (Inherited) of CAs associated with cerebellar ataxia
16) Confidence 0.06 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 1.10 Pain Relevance 0.12
TREATMENTS OF CAS
Positive_regulation (TREATMENTS) of CAS
17) Confidence 0.06 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 2.33 Pain Relevance 0.11
Both mammals and humans exposed to As had increased frequencies of MN and CAs, which led to SCE abnormalities (Wilson et al. 2002).
Positive_regulation (increased) of CAs associated with chromosome aberrations and congenital anomalies
18) Confidence 0.05 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.35 Pain Relevance 0
Blood samples from patients were collected into sodium citrate vacuum tubes as follows: immediately before anesthesia induction (T1); before incision (T2), before vascular clamping (aortic clamping (AAS patients) or carotid artery clamping (CAS patients)) (T3), after blood reperfusion (T4) during the surgery, and on postoperative Days 1 (POD1) and 2 (POD2) after the surgery.
Positive_regulation (clamping) of CAS in blood associated with anesthesia
19) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.08 Pain Relevance 0.40
As shown in Table 1, the group of patients who underwent AAS was not statistically different from those who underwent CAS.
Positive_regulation (underwent) of CAS
20) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.22 Pain Relevance 0.04

General Comments

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