INT340300

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Context Info
Confidence 0.08
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.68
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Ea1 (Mus musculus)
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 246 100.00 Very High Very High Very High
Acupuncture 30 85.80 High High
Osteoarthritis 3 81.20 Quite High
tolerance 21 80.44 Quite High
Fibrositis 3 80.20 Quite High
Pain 3 79.64 Quite High
Spinal cord 3 73.28 Quite High
Central nervous system 3 71.68 Quite High
Neuropeptide 6 66.08 Quite High
cOX1 3 23.56 Low Low
Disease Link Frequency Relevance Heat
Insulin Resistance 78 99.36 Very High Very High Very High
Diabetes Mellitus 42 94.96 High High
Obesity 36 93.76 High High
Disease 9 84.00 Quite High
Knee Osteoarthritis 3 81.20 Quite High
Impaired Glucose Tolerance 9 80.44 Quite High
Sleep Disorders 3 80.20 Quite High
Pain 3 79.64 Quite High
Stress 6 56.76 Quite High
Hyperglycemia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EA increased SIRT1 protein expression and upregulated PGC-1?
EA Positive_regulation (increased) of Gene_expression (expression) of SIRT1 protein associated with electroacupuncture
1) Confidence 0.08 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 1.03 Pain Relevance 0.61
EA significantly increased SIRT1 protein levels in db/db and db/m mice (Figure 2), but it produced no significant effect on SIRT1 mRNA levels (Figure 3(a)).
EA Positive_regulation (increased) of Gene_expression (levels) of SIRT1 protein associated with electroacupuncture
2) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.14 Pain Relevance 0.44
Strikingly, EA likewise induced SIRT1 protein expression, which was concordant with increased PGC-1?
EA Positive_regulation (induced) of Gene_expression (expression) of SIRT1 protein associated with electroacupuncture
3) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.52 Pain Relevance 0.45

General Comments

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