INT340504

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Agtr1a, Pik3cb) endosome (Agtr1a) aging (Agtr1a)
Golgi apparatus (Agtr1a) signal transducer activity (Agtr1a) cytosol (Pik3cb)
Anatomy Link Frequency
hearts 2
Agtr1a (Rattus norvegicus)
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1 46.32 Quite Low
metalloproteinase 1 16.48 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 181 100.00 Very High Very High Very High
Myocardial Infarction 51 95.28 Very High Very High Very High
Diabetic Cardiomyopathies 105 82.20 Quite High
Apoptosis 3 79.76 Quite High
Stress 3 66.12 Quite High
Diabetes Complications 2 42.24 Quite Low
Pressure And Volume Under Development 28 5.00 Very Low Very Low Very Low
Diabetic Nephropathy 26 5.00 Very Low Very Low Very Low
Metabolic Syndrome 25 5.00 Very Low Very Low Very Low
Coronary Artery Disease 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One study examined the hypothesis that phosphorylation of Janus kinase 2 (Jak2) upstream of PI3K is impaired in diabetic hearts by an AT1 receptor-mediated mechanism.
AT1 receptor Negative_regulation (impaired) of Phosphorylation (phosphorylation) of PI3K in hearts associated with diabetes mellitus
1) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.16 Pain Relevance 0

General Comments

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