INT34054

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 3.69
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
blood 6
mononuclear cells 6
Th1 cells 2
lymphocytes 2
respiratory 2
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
Opioid 12 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
cINOD 7 99.68 Very High Very High Very High
narcan 6 99.68 Very High Very High Very High
Inflammation 4 99.30 Very High Very High Very High
Neuropeptide 2 98.40 Very High Very High Very High
anesthesia 14 86.48 High High
depression 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 40 99.76 Very High Very High Very High
INFLAMMATION 7 99.56 Very High Very High Very High
Necrosis 3 99.52 Very High Very High Very High
Fever 2 98.70 Very High Very High Very High
Obesity 1 97.72 Very High Very High Very High
Injury 5 96.66 Very High Very High Very High
Disease 3 93.16 High High
Acute Disease 1 90.36 High High
Bacterial Infection 1 88.72 High High
Infection 4 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, the present data provide clear evidence for concentration-dependent effects of beta-adrenoceptor agonists on the IL-4 and IFN-gamma production by human PBMC.
Regulation (effects) of Gene_expression (production) of IFN-gamma in PBMC associated with agonist
1) Confidence 0.42 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0 Pain Relevance 0.29
Several cases of liver injury related to administration of drugs appear to be initiated or intensified by upper respiratory febrile illnesses and/or inflammation states, which stimulate sometimes dysregulated production of interferon gamma and/or other proinflammatory cytokines/growth factors.
Regulation (dysregulated) of Gene_expression (production) of interferon gamma in respiratory associated with inflammation, injury, fever and cytokine
2) Confidence 0.33 Published 2005 Journal Am J Ther Section Abstract Doc Link 15891270 Disease Relevance 1.21 Pain Relevance 0.45
Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production.
Regulation (regulate) of Gene_expression (production) of IFN-gamma in lymphocytes associated with inflammation, cinod and cytokine
3) Confidence 0.25 Published 1995 Journal Cytokine Section Title Doc Link 8589268 Disease Relevance 0.33 Pain Relevance 0.64
Opioid peptides modulate production of interferon gamma by human mononuclear cells.
Regulation (modulate) of Gene_expression (production) of interferon gamma in mononuclear cells associated with opioid
4) Confidence 0.23 Published 1986 Journal Cell. Immunol. Section Title Doc Link 3026654 Disease Relevance 0 Pain Relevance 0.80
The purpose of this study was to examine the effect of melatonin on the production of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) by peripheral blood mononuclear cells (PBMC) in culture.
Spec (examine) Regulation (effect) of Gene_expression (production) of IFN gamma in blood associated with necrosis and cancer
5) Confidence 0.20 Published 1994 Journal J. Pineal Res. Section Abstract Doc Link 7722866 Disease Relevance 0.30 Pain Relevance 0.10
The effect of the opioid peptides beta-endorphin and Met-enkephalin on interferon gamma (IFN) production by concanavalin A-stimulated human mononuclear cells was examined.
Regulation (effect) of Gene_expression (production) of interferon gamma in mononuclear cells associated with enkephalin and opioid
6) Confidence 0.17 Published 1986 Journal Cell. Immunol. Section Abstract Doc Link 3026654 Disease Relevance 0 Pain Relevance 0.64
Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors.
Regulation (effect) of Gene_expression (production) of IFN gamma in blood
7) Confidence 0.15 Published 1994 Journal J. Pineal Res. Section Title Doc Link 7722866 Disease Relevance 0.27 Pain Relevance 0.10
The purpose of this study was to examine the effect of melatonin on the production of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) by peripheral blood mononuclear cells (PBMC) in culture.
Spec (examine) Regulation (effect) of Gene_expression (production) of interferon gamma in blood associated with necrosis and cancer
8) Confidence 0.15 Published 1994 Journal J. Pineal Res. Section Abstract Doc Link 7722866 Disease Relevance 0.30 Pain Relevance 0.10
All the above factors affect IFG-1 levels.
Regulation (affect) of Gene_expression (levels) of IFG-1
9) Confidence 0.02 Published 2007 Journal BMC Endocr Disord Section Body Doc Link PMC2151943 Disease Relevance 1.13 Pain Relevance 0.06
Th1 cells produce interferon gamma and are responsible for cell-mediated immunity.
Regulation (responsible) of Gene_expression (produce) of interferon gamma in Th1 cells
10) Confidence 0.01 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9842841 Disease Relevance 0.17 Pain Relevance 0.58

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