INT340562

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mstn, Mapk1) nucleoplasm (Mapk1) mitochondrion (Mapk1)
protein complex (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
myocytes 1
skeletal muscle 1
Mstn (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 18 100.00 Very High Very High Very High
agonist 2 11.28 Low Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 26 95.92 Very High Very High Very High
Cancer 86 94.48 High High
Appetite Loss 42 93.92 High High
Frailty 40 90.04 High High
Hypertrophy 6 45.20 Quite Low
Stress 2 21.44 Low Low
Aging 8 15.92 Low Low
Body Weight 12 5.00 Very Low Very Low Very Low
Carcinoma 8 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERK can be activated in the skeletal muscle by several factors, such as cytokines, myostatin, or IGF-1.
myostatin Positive_regulation (activated) of ERK in skeletal muscle associated with cytokine
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.65 Pain Relevance 0.09
Finally, myostatin was proposed to activate ERK and to repress the differentiation program in differentiating C2C12 myocytes [32].
myostatin Positive_regulation (activate) of ERK in myocytes
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.51 Pain Relevance 0.08

General Comments

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