INT34057

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Context Info
Confidence 0.58
First Reported 1986
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 65
Total Number 68
Disease Relevance 43.46
Pain Relevance 17.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T-cell 11
hepatocytes 6
blood 6
NK cells 3
spleen 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 931 100.00 Very High Very High Very High
Inflammation 928 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
Morphine 24 99.98 Very High Very High Very High
Cannabinoid 2 99.98 Very High Very High Very High
agonist 68 99.88 Very High Very High Very High
Multiple sclerosis 578 99.82 Very High Very High Very High
cINOD 76 99.74 Very High Very High Very High
methotrexate 80 99.70 Very High Very High Very High
Enkephalin 6 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 984 100.00 Very High Very High Very High
Cancer 801 100.00 Very High Very High Very High
Recurrence 255 100.00 Very High Very High Very High
Necrosis 84 100.00 Very High Very High Very High
Diabetes Mellitus 48 100.00 Very High Very High Very High
Infection 537 99.92 Very High Very High Very High
Multiple Sclerosis 492 99.82 Very High Very High Very High
Disease 899 99.42 Very High Very High Very High
Hepatitis C Virus Infection 244 99.40 Very High Very High Very High
Systemic Lupus Erythematosus 573 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro exposure of rodent and human lymphocytes to cannabinoids depresses their transformation, natural killer activity, and interferon production.
Negative_regulation (depresses) of Gene_expression (production) of interferon in lymphocytes associated with cannabinoid
1) Confidence 0.58 Published 1987 Journal Adv Alcohol Subst Abuse Section Abstract Doc Link 3329450 Disease Relevance 0.15 Pain Relevance 0.43
PPAR ligands inhibit the proliferation of T lymphocytes as well as of B cells [71] and repress the production of IFN-?
Negative_regulation (repress) of Gene_expression (production) of IFN in B cells
2) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.34 Pain Relevance 0.16
NSAIDs selectively inhibited interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha production by natural killer (NK) and gammadelta T cells with each NSAID displaying its own unique pattern of inhibition, while sparing that by acquired immune cells.
Negative_regulation (inhibited) of Gene_expression (production) of IFN in immune cells associated with necrosis, cancer and cinod
3) Confidence 0.41 Published 2006 Journal Exp. Dermatol. Section Abstract Doc Link 17083365 Disease Relevance 0.77 Pain Relevance 0.94
Cell loss rates of IFN-?
Negative_regulation (loss) of Gene_expression (rates) of IFN
4) Confidence 0.41 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.06 Pain Relevance 0.12
In contrast, we observe significant reductions in serine 727 phosphorylation with apigenin in N9 microglia and luteolin in both N9 and primary microglia in the presence of IFN-?
Negative_regulation (microglia) of Gene_expression (presence) of IFN in microglia
5) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.47 Pain Relevance 0
Predicted ranges for IFN-?
Negative_regulation (Predicted) of Gene_expression (ranges) of IFN
6) Confidence 0.41 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.52 Pain Relevance 0.09
The suppression of clinical EAN was accompanied in vitro by a marked reduction in antigen-specific T-cell proliferation and IFN-gamma synthesis by spleen cells from sTNFR I-treated mice, compared to control mice treated with PBS.
Negative_regulation (reduction) of Gene_expression (synthesis) of IFN in spleen associated with neuritis
7) Confidence 0.41 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 12609491 Disease Relevance 1.10 Pain Relevance 0.76
The PC-IFN soma is triangular or rounded and measures 16??
Negative_regulation (The) of Gene_expression (soma) of PC-IFN in soma
8) Confidence 0.37 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC3006658 Disease Relevance 0.09 Pain Relevance 0.03
When 10(-8) M naloxone was included in cultures containing 10(-12) M beta-endorphin or Met-enkephalin no significant inhibition of the effect of either opioid on IFN production was observed.
Negative_regulation (inhibition) of Gene_expression (production) of IFN associated with narcan, enkephalin and opioid
9) Confidence 0.37 Published 1986 Journal Cell. Immunol. Section Abstract Doc Link 3026654 Disease Relevance 0 Pain Relevance 1.12
Decreased production of Interleukin(IL)-12, IL-2 and Interferon (IFN)-g accompanied by an increased secretion of IL-4 are the main features of this defective immunological response.
Negative_regulation (Decreased) of Gene_expression (production) of Interferon
10) Confidence 0.35 Published 2006 Journal Curr. Med. Chem. Section Abstract Doc Link 17073638 Disease Relevance 1.28 Pain Relevance 0.15
The main difference in T-cell reactivity of patients treated with IFN-ribavirin was a significant decrease of the expression of IFN-?
Negative_regulation (decrease) of Gene_expression (expression) of IFN in T-cell
11) Confidence 0.29 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC2990099 Disease Relevance 1.02 Pain Relevance 0.04
Decreased production of Interleukin(IL)-12, IL-2 and Interferon (IFN)-g accompanied by an increased secretion of IL-4 are the main features of this defective immunological response.
Negative_regulation (Decreased) of Gene_expression (production) of IFN
12) Confidence 0.26 Published 2006 Journal Curr. Med. Chem. Section Abstract Doc Link 17073638 Disease Relevance 1.28 Pain Relevance 0.15
We thus examined whether morphine, the active metabolite of heroin, has the ability to inhibit intrahepatic interferon (IFN)- alpha expression, facilitating HCV replication in human hepatocytes.
Spec (whether) Negative_regulation (inhibit) of Gene_expression (expression) of IFN in hepatocytes associated with hepatitis c virus infection and morphine
13) Confidence 0.21 Published 2007 Journal J. Infect. Dis. Section Abstract Doc Link 17674315 Disease Relevance 0.88 Pain Relevance 0.62
Investigation of the mechanism responsible for the morphine action revealed that morphine inhibited expression of IFN regulatory factor 5 in the hepatocytes.
Negative_regulation (inhibited) of Gene_expression (expression) of IFN in hepatocytes associated with morphine
14) Confidence 0.21 Published 2007 Journal J. Infect. Dis. Section Abstract Doc Link 17674315 Disease Relevance 0.83 Pain Relevance 0.72
Morphine inhibited intrahepatic IFN- alpha expression, which was associated with an increase in HCV replication in hepatocytes.
Negative_regulation (inhibited) of Gene_expression (expression) of IFN in hepatocytes associated with hepatitis c virus infection and morphine
15) Confidence 0.21 Published 2007 Journal J. Infect. Dis. Section Abstract Doc Link 17674315 Disease Relevance 0.88 Pain Relevance 0.66
T cells from RA synovium are characterized by a reduced production of IFN-?
Negative_regulation (reduced) of Gene_expression (production) of IFN in T cells associated with rheumatoid arthritis
16) Confidence 0.20 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.24 Pain Relevance 0.54
Currently, interferon (IFN) products, including IFN ?
Negative_regulation (Currently) of Gene_expression (products) of IFN
17) Confidence 0.18 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2951744 Disease Relevance 0.73 Pain Relevance 0.38
Currently, interferon (IFN) products, including IFN ?
Negative_regulation (Currently) of Gene_expression (products) of interferon
18) Confidence 0.18 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2951744 Disease Relevance 0.72 Pain Relevance 0.38
By cleaving IPS-1 and inactivating TRIF, HCV disrupts the ability of a cell to detect its presence, as a consequence, IFN production is diminished and host defenses are impaired [23].
Negative_regulation (diminished) of Gene_expression (production) of IFN associated with hepatitis c virus infection
19) Confidence 0.18 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.60 Pain Relevance 0.03
neutralizing antibody, which may block the regulatory properties of IFN-?
Negative_regulation (block) of Gene_expression (properties) of IFN
20) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.48 Pain Relevance 0.21

General Comments

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