INT34058

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.11
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FMR1) transport (FMR1) mRNA binding (FMR1)
nucleolus (FMR1) RNA binding (FMR1) nucleus (FMR1)
Anatomy Link Frequency
lymphocytes 1
heart 1
sympathetic nervous system 1
FMR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 2 97.76 Very High Very High Very High
Endogenous opioid 1 75.00 Quite High
fluoxetine 1 63.92 Quite High
long-term potentiation 14 54.08 Quite High
Hippocampus 4 45.12 Quite Low
antagonist 2 43.36 Quite Low
Central nervous system 1 10.32 Low Low
amygdala 58 5.00 Very Low Very Low Very Low
nMDA receptor 25 5.00 Very Low Very Low Very Low
Glutamate 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 12 100.00 Very High Very High Very High
Premature Ovarian Failure 6 100.00 Very High Very High Very High
Intellectual Impairment 25 99.76 Very High Very High Very High
Dyspnea 4 99.74 Very High Very High Very High
Fragile X Syndrome 3 99.20 Very High Very High Very High
Premature Menopause 1 98.20 Very High Very High Very High
Autoimmune Disease 27 97.16 Very High Very High Very High
Pernicious Anemia 3 94.80 High High
Diabetes Mellitus 7 93.92 High High
Autism 314 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemistry of blood smears showed fragile X mental retardation-1 protein (FMRP) expression in 63.5% of lymphocytes.
Gene_expression (expression) of FMRP in lymphocytes associated with intellectual impairment
1) Confidence 0.75 Published 1999 Journal Am. J. Med. Genet. Section Abstract Doc Link 10208169 Disease Relevance 0.64 Pain Relevance 0.06
To further study the neurobiological causes of Fragile X Syndrome a mutant mouse was created lacking the expression of the FMR1 gene (Consortium, 1994).
Gene_expression (expression) of FMR1 gene associated with fragile x syndrome
2) Confidence 0.42 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 1.04 Pain Relevance 0.03
Several forms of POF are not of autoimmune etiology, however in a majority of our patients with premature menopause other autoimmune disorders have been observed.
Gene_expression (etiology) of POF associated with premature menopause, autoimmune disease and premature ovarian failure
3) Confidence 0.23 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC3005832 Disease Relevance 1.77 Pain Relevance 0
If dyspnea were due to congestive heart failure, for which Simvastatin might be prescribed, it would be expected and not submitted to the AERS database as an adverse drug event.
Gene_expression (prescribed) of congestive heart failure in heart associated with heart rate under development and dyspnea
4) Confidence 0.06 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2967748 Disease Relevance 0.88 Pain Relevance 0
We studied the role of endogenous opiates and their interrelationships with the sympathetic nervous system in an experimental preparation of right-sided congestive heart failure (CHF) produced by surgical tricuspid avulsion and progressive pulmonary arterial constriction.
Gene_expression (produced) of congestive heart failure in sympathetic nervous system associated with heart rate under development and opiate
5) Confidence 0.00 Published 1987 Journal Circulation Section Abstract Doc Link 3026683 Disease Relevance 0.78 Pain Relevance 0.17

General Comments

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