INT340595

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.86
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (Wnt3a) extracellular space (Wnt3a) extracellular region (Wnt3a)
proteinaceous extracellular matrix (Wnt3a) plasma membrane (Wnt3a) molecular_function (Wnt3a)
Anatomy Link Frequency
dentate gyrus 2
Wnt3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 330 99.98 Very High Very High Very High
antagonist 10 93.28 High High
sSRI 25 77.76 Quite High
Serotonin 15 73.84 Quite High
Hippocampus 15 68.72 Quite High
depression 25 5.00 Very Low Very Low Very Low
antidepressant 25 5.00 Very Low Very Low Very Low
Intracerebroventricular 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 95 100.00 Very High Very High Very High
Targeted Disruption 20 82.12 Quite High
Depression 25 5.00 Very Low Very Low Very Low
Hypersensitivity 25 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the expression of Wnt3a, also known to be closely involved in neurogenesis [3], [22], [33], [34] was, as expected, increased by fluoxetine, but this was not prevented by K252a.
Positive_regulation (increased) of Gene_expression (expression) of Wnt3a associated with neurodegenerative disease and fluoxetine
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.35 Pain Relevance 0.46
However, it did not prevent increased Wnt3a expression, suggesting that the latter is not a sufficient event for increased progenitor cell mitosis.
Positive_regulation (increased) of Gene_expression (expression) of Wnt3a
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.38 Pain Relevance 0.48
There was also no observable change in either pCREB or Wnt3a at 7 days, but by 14 days the expression of both was clearly increased (Figure 2C, D).


Positive_regulation (increased) of Gene_expression (expression) of Wnt3a
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0 Pain Relevance 0.91
These experiments show that (i) Fluoxetine increased Ki67 counts, as well as pCREB and Wnt3a expression in the dentate gyrus.
Positive_regulation (increased) of Gene_expression (expression) of Wnt3a in dentate gyrus associated with fluoxetine
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965105 Disease Relevance 0.07 Pain Relevance 0.63
As in experiment 1, pCREB was reduced in fluoxetine and K252a-treated animals, but increased expression of Wnt3a still occurred in fluoxetine-treated animals given K252a.
Positive_regulation (increased) of Gene_expression (expression) of Wnt3a associated with fluoxetine
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.06 Pain Relevance 0.63

General Comments

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