INT340603

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.49
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (Wnt3a) extracellular space (Wnt3a) extracellular region (Wnt3a)
proteinaceous extracellular matrix (Wnt3a) plasma membrane (Wnt3a) molecular_function (Wnt3a)
Anatomy Link Frequency
dentate gyrus 2
Wnt3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 12 100.00 Very High Very High Very High
fluoxetine 396 99.84 Very High Very High Very High
Serotonin 18 86.40 High High
sSRI 30 84.52 Quite High
Hippocampus 18 76.48 Quite High
depression 30 5.00 Very Low Very Low Very Low
antidepressant 30 5.00 Very Low Very Low Very Low
Intracerebroventricular 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 114 89.08 High High
Targeted Disruption 24 72.40 Quite High
Depression 30 5.00 Very Low Very Low Very Low
Hypersensitivity 30 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 6 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, adding K252a to fluoxetine did not prevent the latter's stimulating effect on Wnt3a expression (Figure 1D).
Regulation (effect) of Gene_expression (expression) of Wnt3a associated with fluoxetine
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0 Pain Relevance 0.86
The second experiment began by confirming, under our conditions, that a 7-day treatment with fluoxetine had no discernible effect on progenitor mitosis, or pCREB and Wnt3a expression, whereas after 14 days all three were stimulated.
Regulation (effect) of Gene_expression (expression) of Wnt3a associated with fluoxetine
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.33 Pain Relevance 0.57
The first part of this experiment showed that 7 days treatment with fluoxetine had no effect on Ki67 labelled cells, or on the expression of either pCREB or Wnt3a.
Regulation (effect) of Gene_expression (expression) of Wnt3a associated with fluoxetine
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0 Pain Relevance 0.54
This paper explores the role of BDNF in this process, using the effect of a Trk antagonist (K252a) on the labelling of progenitor cells with the mitosis marker Ki67 and the associated expression of pCREB and Wnt3a.
Regulation (effect) of Gene_expression (expression) of Wnt3a associated with antagonist
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965105 Disease Relevance 0.08 Pain Relevance 0.64
As in Experiment 1, pCREB expression was inhibited by 14 days K252a treatment (not shown in Figure 3, since there was effectively no signal in the K252a treated animals) but Wnt3a expression was not altered, even though Ki67 expression was reduced (Figure 3B).


Regulation (altered) of Gene_expression (expression) of Wnt3a
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0 Pain Relevance 0.56
Table 1 summarises the results of these two experiments on the expression of Ki67, pCREB and Wnt3a in the dentate gyrus.



Regulation (results) of Gene_expression (expression) of Wnt3a in dentate gyrus
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.08 Pain Relevance 0.58

General Comments

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