INT340606

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (Wnt3a) extracellular space (Wnt3a) extracellular region (Wnt3a)
proteinaceous extracellular matrix (Wnt3a) plasma membrane (Wnt3a) molecular_function (Wnt3a)
Anatomy Link Frequency
dentate gyrus 1
neural 1
Wnt3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 132 99.92 Very High Very High Very High
depression 10 41.04 Quite Low
sSRI 10 5.00 Very Low Very Low Very Low
antidepressant 10 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Serotonin 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 38 97.92 Very High Very High Very High
Depression 10 41.04 Quite Low
Hypersensitivity 10 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of fluoxetine to increase Wnt3a is consistent with this drug's reported induction of neural plasticity [45], [46], [47].
Positive_regulation (increase) of Wnt3a in neural associated with fluoxetine
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.25 Pain Relevance 0.26
However, increased Wnt3a may be an essential ingredient of the stimulatory process, since we never observed one without the other, and inhibition of Wnt signalling reduces adult neurogenesis in the dentate gyrus [3].
Positive_regulation (increased) of Wnt3a in dentate gyrus associated with neurodegenerative disease
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.24 Pain Relevance 0.14

General Comments

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